129-06-6|Warfarin sodiumProducts Supply - Chemical intermediates Network

Warfarin sodium cas no:129-06-6

Synonyms: 3-(a-Acetonylbenzyl)-4-hydroxycoumarinsodium;Aldocumar;Athrombin;Coumadin;Coumadine;Dimantil;Marevam;Orfarin;Panwarfin;Prothromadin;Simarc 2;Sodiumwarfarin;Sofarin;Tintorane;Varfine;Waran;Warfarina;Warfil 5;Zoocoumarin sodium salt;2H-1-Benzopyran-2-one,4-hydroxy-3-(3-oxo-1-phenylbutyl)-, sodium salt (9CI);Coumarin, 3-(a-acetonylbenzyl)-4-hydroxy-, sodium salt (8CI);

Identification

NameWarfarin sodium
CAS129-06-6
Synonyms3-(a-Acetonylbenzyl)-4-hydroxycoumarinsodium;Aldocumar;Athrombin;Coumadin;Coumadine;Dimantil;Marevam;Orfarin;Panwarfin;Prothromadin;Simarc 2;Sodiumwarfarin;Sofarin;Tintorane;Varfine;Waran;Warfarina;Warfil 5;Zoocoumarin sodium salt;2H-1-Benzopyran-2-one,4-hydroxy-3-(3-oxo-1-phenylbutyl)-, sodium salt (9CI);Coumarin, 3-(a-acetonylbenzyl)-4-hydroxy-, sodium salt (8CI);
EINECS(EC#)204-929-4
Molecular FormulaC₁₉H₁₆NaO₄
Molecular Weight330.31

Chemical Properties

Appearancewhite or yellowish powder
storage tempStore at away from heat and open flame. Do not store near feeds and foodstuffs and keep away from children, domestic animals, pets, or wildlife.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(a)

Safety Data

Hazard T+:Verytoxic;
Risk R61;R28
Safety

Safety Information of?Warfarin sodium (CAS NO.129-06-6):
Hazard Codes:T+
Risk Statements:61-28
Safety Statements:53-36/37/39-45
RIDADR:UN 1544 6.1/PG 2
WGK Germany:1
RTECS:GN4725000
HazardClass:6.1(a)
PackingGroup:II
Poison to humans by ingestion. Experimental poison by ingestion and intravenous routes. Human systemic effects by ingestion: dermatitis. Human reproductive effects by ingestion: fetotoxicity, abnormal condition of newborn at birth, other newborn physical effects, and teratogenic effects including developmental abnormalities of the eye and ear, craniofacial area, skin and appendages, musculoskeletal system, cardiovascular system, and gastrointestinal system of the fetus. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. An anticoagulant drug. When heated to decomposition it emits toxic fumes of Na₂O.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LD50	intravenous	200mg/kg (200mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: HEMORRHAGE SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
child	TDLo	oral	4mg/kg (4mg/kg)	BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)	American Journal of Diseases of Children. Vol. 147, Pg. 609, 1993.
dog	LD50	intravenous	200mg/kg (200mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: HEMORRHAGE SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
dog	LD50	oral	200mg/kg (200mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
guinea pig	LD50	oral	182mg/kg (182mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
guinea pig	LDLo	intravenous	543mg/kg (543mg/kg)	?	Therapie. Vol. 18, Pg. 921, 1963.
mouse	LD50	intravenous	160mg/kg (160mg/kg)	?	"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 123, 1969.
mouse	LD50	oral	374mg/kg (374mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
rabbit	LD50	intravenous	100mg/kg (100mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: HEMORRHAGE SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
rabbit	LD50	oral	800mg/kg (800mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
rat	LD50	intravenous	25mg/kg (25mg/kg)	?	"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 123, 1969.
rat	LD50	oral	8700ug/kg (8.7mg/kg)	BLOOD: HEMORRHAGE	Pharmacological Research Communications. Vol. 10, Pg. 445, 1978.
women	TDLo	oral	300ug/kg/2D (0.3mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Archives of Dermatology. Vol. 116, Pg. 444, 1980.

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Warfarin sodium cas no:129-06-6

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