3,5-Pyrazolidinedione,4-butyl-1-(4-hydroxyphenyl)-2-phenyl- cas no:129-20-4

Name3,5-Pyrazolidinedione,4-butyl-1-(4-hydroxyphenyl)-2-phenyl-
CAS129-20-4
Synonyms3,5-Pyrazolidinedione,4-butyl-1-(p-hydroxyphenyl)-2-phenyl- (6CI,7CI,8CI); 1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione;1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine;1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine;1-p-Hydroxyphenyl-2-phenyl-3,5-dioxo-4-n-butylpyrazolidine;4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine;4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,4-pyrazolidinedione;4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,5-pyrazolidinedione; Butapirone;Californit; Crovaril; Flamaril; Floghene; Flogitolo; Flogoril; Frabel; G 27202;Metabolite I; NSC 526053; Neo-Farmadol; Offitril; Oxalid; Oxazolidin;Oxyphenbutazone; Oxyphenobutazone; Oxyphenylbutazone; Rapostan; Ro 04-4410;Romaxin; Suganril; Tandacote; Tandearil; Tanderil; Telidal; Tendearil;Visubutina; p-Hydroxyphenylbutazone; p-Oxyphenylbutazone
EINECS(EC#)204-936-2
Molecular FormulaC19H20 N2 O3
Molecular Weight324.41

refractive index1.61

Safety

A poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic to humans by ingestion. Human systemic effects: agranulocytosis, dermatitis, diarrhea, fever, hemorrhage, hepatitis, hypermotility, nausea or vomiting, salivary gland changes, thrombocytopenia. Experimental reproductive effects. Questionable carcinogen. Mutation data reported. Used as an anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	420mg/kg/4W-I (420mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" BLOOD: AGRANULOCYTOSIS BLOOD: THROMBOCYTOPENIA	British Medical Journal. Vol. 2, Pg. 1517, 1962.
dog	LD50	intravenous	178mg/kg (178mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.
guinea pig	LD50	oral	1165mg/kg (1165mg/kg)		Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 11, Pg. 220, 1974.
hamster	LD50	oral	1180mg/kg (1180mg/kg)		Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
man	TDLo	oral	27mg/kg/14D (27mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: HEMORRHAGE	Laekartidningen. Medical News. Vol. 63, Pg. 53, 1966.
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)		National Technical Information Service. Vol. AD414-344,
mouse	LD50	intravenous	52mg/kg (52mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 129, 1960.
mouse	LD50	oral	330mg/kg (330mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63, Pg. 43, 1967.
rabbit	LD50	intravenous	104mg/kg (104mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Annals of the New York Academy of Sciences. Vol. 86, Pg. 263, 1960.
rat	LD50	intraperitoneal	145mg/kg (145mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63, Pg. 43, 1967.
rat	LD50	intravenous	68mg/kg (68mg/kg)		Medicina Experimentalis. Vol. 6, Pg. 88, 1962.
rat	LD50	oral	329mg/kg (329mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63, Pg. 43, 1967.
women	TDLo	oral	24mg/kg/4D (24mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS ENDOCRINE: OTHER CHANGES	JAMA, Journal of the American Medical Association. Vol. 238, Pg. 1399, 1977.
women	TDLo	oral	50mg/kg/7D (50mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Laekartidningen. Medical News. Vol. 63, Pg. 53, 1966.