130-89-2|Cinchonan-9-ol,6'-methoxy-, hydrochloride (1:1), (8alpha,9R)-Products Supply

Cinchonan-9-ol,6'-methoxy-, hydrochloride (1:1), (8alpha,9R)- cas no:130-89-2

Synonyms: Cinchonan-9-ol,6'-methoxy-, monohydrochloride, (8a,9R)- (9CI);Quinine, monohydrochloride (8CI);Chinimetten;Quininehydrochloride;Quinine muriate;

Identification

NameCinchonan-9-ol,6'-methoxy-, hydrochloride (1:1), (8alpha,9R)-
CAS130-89-2
SynonymsCinchonan-9-ol,6'-methoxy-, monohydrochloride, (8a,9R)- (9CI);Quinine, monohydrochloride (8CI);Chinimetten;Quininehydrochloride;Quinine muriate;
EINECS(EC#)205-001-1
Molecular FormulaC20H24 N2 O2 . Cl H
Molecular Weight360.92

Chemical Properties

refractive index1.638

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xi
Risk 36/37/38
Safety

Poison by ingestion, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects by intravenous route: convulsions or effect on seizure threshold, muscle contraction or spasticity, and nausea or vomiting. Mutation data reported. Used as a local anesthetic. When heated to decomposition it emits very toxic fumes of NO_x and HCl. Safety Information of Quinine hydrochloride (CAS NO.130-89-2):
Hazard Codes: Xi
Xi: Irritant
Risk Statements 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	80mg/kg (80mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 30, Pg. 327, 1927.
chicken	LDLo	oral	857mg/kg (857mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 201, Pg. 402, 1943.
dog	LDLo	intravenous	75mg/kg (75mg/kg)	BEHAVIORAL: EXCITEMENT	Journal of Pharmacology and Experimental Therapeutics. Vol. 82, Pg. 266, 1944.
dog	LDLo	subcutaneous	180mg/kg (180mg/kg)		Zeitschrift fuer die Gesamte Experimentelle Medizin. Vol. 11, Pg. 257, 1920.
frog	LDLo	unreported	350mg/kg (350mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 53, 1916.
guinea pig	LDLo	oral	300mg/kg (300mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 12, Pg. 497, 1904.
human	LDLo	intravenous	230ug/kg (0.23mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: NAUSEA OR VOMITING	Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 17, Pg. 363, 1883.
mouse	LD50	intraperitoneal	189mg/kg (189mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 133, 1947.
mouse	LD50	intravenous	68300ug/kg (68.3mg/kg)		Toxicology and Applied Pharmacology. Vol. 1, Pg. 454, 1959.
mouse	LD50	oral	1160mg/kg (1160mg/kg)		British Journal of Pharmacology and Chemotherapy. Vol. 6, Pg. 185, 1951.
mouse	LDLo	subcutaneous	700mg/kg (700mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 53, 1916.
rabbit	LDLo	intravenous	25mg/kg (25mg/kg)	BEHAVIORAL: EXCITEMENT	Journal of Pharmacology and Experimental Therapeutics. Vol. 82, Pg. 266, 1944.
rabbit	LDLo	oral	800mg/kg (800mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 12, Pg. 497, 1904.
rabbit	LDLo	subcutaneous	250mg/kg (250mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 12, Pg. 497, 1904.
rat	LD50	oral	620mg/kg (620mg/kg)		Farm Chemicals Handbook. Vol. -, Pg. C218, 1991.
rat	LDLo	intramuscular	300mg/kg (300mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 63, Pg. 122, 1938.
rat	LDLo	intravenous	75mg/kg (75mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 63, Pg. 122, 1938.
rat	LDLo	subcutaneous	790mg/kg (790mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Zeitschrift fuer die Gesamte Experimentelle Medizin. Vol. 11, Pg. 257, 1920.

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Cinchonan-9-ol,6'-methoxy-, hydrochloride (1:1), (8alpha,9R)- cas no:130-89-2

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