Quinine cas no:130-95-0

NameQuinine
CAS130-95-0
SynonymsQuinine anhydrous; Quinine hydrochloride dihydrate; Quinine free base; (6-Methoxy-4-quinolyl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol
EINECS(EC#)205-003-2
Molecular FormulaC20H24N2O2
Molecular Weight324.42

AppearanceTriboluminescent, orthorhombic needles from absolute alcohol. Odorless. An alkaloid derived from the bark of the cinchona tree.
alpha-172 o (C=1, ETOH)
refractive index1.625 (15 C)
storage tempStore in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store below 40C.
Sensitive Light Sensitive

Hazardclass6.1(b)

Hazard Xn:Harmful
Risk R22;R36/37/38
Safety

Human poison by unspecified route. Experimental poison by subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Moderately toxic experimentally by ingestion. An experimental teratogen. Human systemic effects by ingestion: visual field changes, tinnitus, and nausea or vomiting. Human teratogenic effects by ingestion: developmental abnormalities of the central nervous system, body wall, and musculoskeletal, cardiovascular, and hepatobiliary systems. Experimental reproductive effects. Mutation data reported. Can cause temporary loss of vision. Quinine dermatitis is an occupational hazard to barbers particularly, and generally to people who work with quinine tonics, medicaments, or cosmetics. An irritant to mucous membranes. Combustible when exposed to heat or flame. Decomposes on exposure to light. When heated to decomposition it emits toxic fumes of NO_x. Used to treat malaria.
Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-42/43-22-20/22-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin. 
R42/43:May cause sensitization by inhalation and skin contact. 
R22:Harmful if swallowed. 
R20/22:Harmful by inhalation and if swallowed. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-26-36/37-45-37/39-36-7 
S22:Do not breathe dust. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S37/39:Wear suitable gloves and eye/face protection. 
S36:Wear suitable protective clothing. 
S7:Keep container tightly closed.
WGK Germany: 3
RTECS of Quinine (CAS NO.130-95-0): VA6020000

HS Code 29392110

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	100mg/kg (100mg/kg)		Rivista di Malariologia. Vol. 11, Pg. 3, 1932.
cat	LDLo	subcutaneous	100mg/kg (100mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 205, Pg. 129, 1948.
dog	LDLo	subcutaneous	180mg/kg (180mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
frog	LDLo	intramuscular	400mg/kg (400mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
frog	LDLo	oral	1500mg/kg (1500mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
frog	LDLo	subcutaneous	200mg/kg (200mg/kg)	BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 205, Pg. 129, 1948.
guinea pig	LD50	oral	1800mg/kg (1800mg/kg)		Schweizerische Medizinische Wochenschrift. Vol. 84, Pg. 351, 1954.
man	LDLo	unreported	294mg/kg (294mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LD50	intraperitoneal	115mg/kg (115mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1760, 1985.
mouse	LD50	intravenous	68mg/kg (68mg/kg)		Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991.
mouse	LDLo	subcutaneous	200mg/kg (200mg/kg)	CARDIAC: OTHER CHANGES BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA BLOOD: OTHER CHANGES	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 205, Pg. 129, 1948.
pigeon	LDLo	intramuscular	500mg/kg (500mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
rabbit	LDLo	intravenous	70mg/kg (70mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
rabbit	LDLo	oral	500mg/kg (500mg/kg)		Rivista di Malariologia. Vol. 11, Pg. 3, 1932.
rabbit	LDLo	subcutaneous	231mg/kg (231mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
rat	LD	intraperitoneal	> 100mg/kg (100mg/kg)		Cancer Research. Vol. 52, Pg. 2797, 1992.
rat	LDLo	oral	800mg/kg (800mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 408, 1950.
rat	LDLo	subcutaneous	200mg/kg (200mg/kg)	CARDIAC: OTHER CHANGES BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA BLOOD: OTHER CHANGES	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 205, Pg. 129, 1948.
women	TDLo	oral	74mg/kg (74mg/kg)	SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR GASTROINTESTINAL: NAUSEA OR VOMITING	American Journal of Ophthalmology. Vol. 90, Pg. 403, 1980.