Yohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, (16b,17a,20a)- cas no:131-03-3

NameYohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, (16b,17a,20a)-
CAS131-03-3
Synonyms20a-Yohimban-16b-carboxylic acid, 17a-hydroxy-, methyl ester (8CI);Rauwolscine (6CI,7CI); Benz[g]indolo[2,3-a]quinolizine, yohimban-16-carboxylicacid deriv.; Corynanthidine; Isoyohimbine; Mesoyohimbine; meso-Yohimbine; a-Yohimbine
EINECS(EC#)205-006-9
Molecular FormulaC21H26 N2 O3
Molecular Weight354.44274

Hazardclass6.1(a)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

ZG1005000

CHEMICAL NAME :

20-alpha-Yohimban-16-beta-carboxylic acid, 17-alpha-hydroxy-, methyl ester

CAS REGISTRY NUMBER :

131-03-3

LAST UPDATED :

198708

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C21-H26-N2-O3

MOLECULAR WEIGHT :

354.49

WISWESSER LINE NOTATION :

T F6 D5 C666 EM ON&&TTTJ TQ UVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

50 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)

REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,447,1961

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,317,1948

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

80 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)

REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,447,1961