Benzeneacetic acid, a-cyclopentyl-a-hydroxy-,1-methyl-3-pyrrolidinyl ester, hydrochloride (1:1) cas no:13118-10-0

NameBenzeneacetic acid, a-cyclopentyl-a-hydroxy-,1-methyl-3-pyrrolidinyl ester, hydrochloride (1:1)
CAS13118-10-0
SynonymsBenzeneaceticacid, a-cyclopentyl-a-hydroxy-, 1-methyl-3-pyrrolidinylester, hydrochloride (9CI); Mandelic acid, a-cyclopentyl-, 1-methyl-3-pyrrolidinyl ester,hydrochloride (6CI,7CI,8CI); 3-Pyrrolidinol, 1-methyl-, a-cyclopentylmandelate (ester),hydrochloride (8CI); 3-Pyrrolidinol, 1-methyl-, a-cyclopentylmandelate, hydrochloride;1-Methyl-3-pyrrolidyl-a-phenylcyclopentane glycolate hydrochloride; 1-Methyl-3-pyrrolidyl-a-phenylcyclopentylglycolatehydrochloride; AHR 376; NSC 172251
EINECS(EC#)236-047-0
Molecular FormulaC18H25 N O3 . Cl H
Molecular Weight339.90

refractive index1.577

Safety Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects by ingestion: hallucinations, distorted perceptions, and toxic psychosis. When heated to decomposition it emits toxic fumes of NOx and HCl.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

OO7340000

CHEMICAL NAME :

Mandelic acid, alpha-cyclopentyl-, 1-methyl-3-pyrrolidinyl ester, hydrochloride

CAS REGISTRY NUMBER :

13118-10-0

LAST UPDATED :

198910

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C18-H25-N-O3.Cl-H

MOLECULAR WEIGHT :

339.90

WISWESSER LINE NOTATION :

T5NTJ A1 COVXQR&- AL5TJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human

DOSE/DURATION :

14 ug/kg/D

TOXIC EFFECTS :

Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis

REFERENCE :

CPAJAK Canadian Psychiatric Association Journal. (Ottawa, Ont., Canada) V.1-23, 1956-78. For publisher information, see CJPSDF. Volume(issue)/page/year: 11,S141,1966

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

500 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 2,523,1960

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

250 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 2,523,1960