Benztropine mesylate cas no:132-17-2
Synonyms: Cobrentin methanesulfonate;endo-3-(Diphenylmethoxy)-8-methyl-8-azoniabicyclo(3.2.1)octane methanesulphonate;(1R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane; methanesulfonic acid;8-Azabicyclo[3.2.1]octane, 3- (diphenylmethoxy)-8-methyl-, endo-, methanesulfonate;Cogentin methanesulfonate;Benzotropine methanesulfonate;(1R,5R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane; methanesulfonic acid;Benztropine mesylate (USP);1-alpha-H,5-alpha-H-Tropane, 3-alpha-(diphenylmethoxy)-, methanesulfonate;8-Azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-, endo-, methanesulfonate;Benztropine methanesulfonate;Benzotropinemesylate;8-Azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-methyl-, endo-, methanesulfonate (9CI);Benztropine mesilate (JAN);Cogentin Mesylate;8-Azabicyclo[3.2.1]octane,3-(diphenylmethoxy)- 8-methyl-,(3-endo)-,methanesulfonate;3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane; methanesulfonic acid;Cogentin (TN);Benzatropine methanesulfonate;3-Diphenyl methoxytropane methanesulfonate;Benztropine mesilate;1alphaH,5alphaH-Tropane, 3alpha-(diphenylmethoxy)-, methanesulfonate (8CI);Tropine benzohydryl ether methanesulfonate;
NameBenztropine mesylate
CAS132-17-2
SynonymsCobrentin methanesulfonate;endo-3-(Diphenylmethoxy)-8-methyl-8-azoniabicyclo(3.2.1)octane methanesulphonate;(1R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane; methanesulfonic acid;8-Azabicyclo[3.2.1]octane, 3- (diphenylmethoxy)-8-methyl-, endo-, methanesulfonate;Cogentin methanesulfonate;Benzotropine methanesulfonate;(1R,5R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane; methanesulfonic acid;Benztropine mesylate (USP);1-alpha-H,5-alpha-H-Tropane, 3-alpha-(diphenylmethoxy)-, methanesulfonate;8-Azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-, endo-, methanesulfonate;Benztropine methanesulfonate;Benzotropinemesylate;8-Azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-methyl-, endo-, methanesulfonate (9CI);Benztropine mesilate (JAN);Cogentin Mesylate;8-Azabicyclo[3.2.1]octane,3-(diphenylmethoxy)- 8-methyl-,(3-endo)-,methanesulfonate;3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane; methanesulfonic acid;Cogentin (TN);Benzatropine methanesulfonate;3-Diphenyl methoxytropane methanesulfonate;Benztropine mesilate;1alphaH,5alphaH-Tropane, 3alpha-(diphenylmethoxy)-, methanesulfonate (8CI);Tropine benzohydryl ether methanesulfonate;
EINECS(EC#)205-048-8
Molecular FormulaC21H25NO.CH4O3S
Molecular Weight403.53496
Appearancewhite, crystalline powder; odourless or almost odourless
storage temp2-8°C
Hazard T: Toxic;
Risk R23/24/25
Safety
Hazard Codes: 
T Toxic.
Risk Statements: 23/24/25
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 36/37/39-45
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
RIDADR: UN 2811 6.1/PG 3
WGK: Germany 3
RTECS: YM3150000
Poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. Human systemic effects by ingestion: psychotropic effects. Mutation data reported.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| cat |
LDLo |
intravenous |
33mg/kg (33mg/kg) |
|
Compilation of LD50 Values of New Drugs. |
| guinea pig |
LD50 |
subcutaneous |
80mg/kg (80mg/kg) |
AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962. |
| human |
TDLo |
oral |
100ug/kg (0.1mg/kg) |
BEHAVIORAL: TOXIC PSYCHOSIS |
Proceedings of the European Society for the Study of Drug Toxicity. Vol. 8, Pg. 59, 1967. |
| mouse |
LD50 |
intraperitoneal |
65mg/kg (65mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 555, 1963. |
| mouse |
LD50 |
intravenous |
24mg/kg (24mg/kg) |
|
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 208, 1972. |
| mouse |
LD50 |
oral |
91mg/kg (91mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 775, 1982. |
| mouse |
LD50 |
subcutaneous |
103mg/kg (103mg/kg) |
|
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 208, 1972. |
| rat |
LD50 |
oral |
940mg/kg (940mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 775, 1982. |
| rat |
LD50 |
subcutaneous |
353mg/kg (353mg/kg) |
|
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 208, 1972. |
