132539-06-1|10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-Products Supply

10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)- cas no:132539-06-1

Synonyms: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine;Olansek;10H-Thieno(2,3-b)(1,5)benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-;Symbyax;Zyprexa (TN);Olanzapine [USAN:INN];2-methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine;

Identification

Name10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-
CAS132539-06-1
Synonyms2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine;Olansek;10H-Thieno(2,3-b)(1,5)benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-;Symbyax;Zyprexa (TN);Olanzapine [USAN:INN];2-methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine;
Molecular FormulaC₁₇H₂₀N₄S
Molecular Weight312.43

Chemical Properties

Appearanceyellowish crystalline powder
refractive index3.3
storage tempStore in original container in a cool dark place.

Safety Data

Safety

Human systemic effects. When heated to decomposition it emits toxic vapors of NO_x and SO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	16560ug/kg/12 (16.56mg/kg)	BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	Journal of Clinical Psychiatry. Vol. 60, Pg. 767, 1999.
human	TDLo	oral	43mg/kg/30W-I (43mg/kg)	?	Journal of Clinical Pyschopharmacology. Vol. 19, Pg. 273, 1999.
man	LDLo	oral	7067ug/kg (7.067mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"	Journal of Forensic Sciences. Vol. 41, Pg. 1252, 1998.
man	TDLo	oral	2570ug/kg/12D (2.57mg/kg)	AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC	Journal of Clinical Pyschopharmacology. Vol. 19, Pg. 192, 1999.
women	LDLo	oral	30mg/kg/22W-I (30mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Annals of Pharmacotherpy. Vol. 33, Pg. 787, 1999.
women	TDLo	oral	400ug/kg (0.4mg/kg)	BEHAVIORAL: REGIDITY VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	American Journal of Psychiatry. Vol. 156, Pg. 1835, 1999.
women	TDLo	oral	12mg/kg (12mg/kg)	BEHAVIORAL: COMA CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Annals of Emergency Medicine. Vol. 32, Pg. 275, 1998.
women	TDLo	oral	12mg/kg/60D-I (12mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS	Annals of Internal Medicine. Vol. 131, Pg. 72, 1999.

supplier list

EASYBUYER LTD.,: Tel:+86-21-35015877 +86-13701868511; Address: Room 407, Building 10, Hi-Shanghai Center, No.990 Dalian Rd,Shanghai 200092 China

grandachem Ltd.: Tel:; Address: 11F, No.Hubin North Road,Siming Area, Xiamen China.

SUNWELL CHEMICALS CO.,LTD.(INTERPHARMA TRADING CO...: Tel:; Address: SUITE 1108,GOLDEN PLAZA,NO.118,QING CHUN ROAD,HANGZHOU,ZHEJIANG,CHINA

Changzhou ComWin Fine Chemicals Co.,Ltd.: Tel:; Address: 24th Floor, Jiaye International Commercial Plaza, 99 Yanling West Road, Changzhou, Jiangsu, China

IFFECT CHEMPHAR CO., LTD.: Tel:86-25-84679300; Address: 509, FuXin International Building, No.359 HongWu R

Shanghai Longschem Co.,Ltd: Tel:; Address: Shanghai Jincheng Road 338 6# 1002 Room

Taizhou Tianrui Chempharm Co., Ltd.: Tel:+86-576-88603301; Address: No.35,Haiwanlangqin ,Jiaojiang Zone,Taizhou City Zhejiang province P.R.China

Beijing Lunarsun Pharmaceutical Co.Ltd.: Tel:086-10-81760039 80771377 80771378 80771379 81760170 81760171 81760172; Address: C1-802, Yangguangguangchang, Anli Road No.68 ,Chaoyang District , 100101 , Beijing , P.R.China

Hangzhou VIWA Co., Ltd.: Tel:0086-571-56836886, 56832058, 56836878; Address: Block B, 5F, Huanglong Hengli Mansion,No.5 Huanglong Road, Hangzhou, China

Jiangsu Tianhe Medicinal Institute Co., Ltd.: Tel:; Address: No.66 Kunlun North Road, Liyang, Jiangsu, China

Melone Pharmaceutical Co., Ltd.: Tel:; Address: Room 2209锛孨o.232, Jinma Road, Development Zone, Dalian, China

Farmamondo: Tel:+41 91 6976370; Address: Farmamondo , Via Volta 2, Chiasso (Switzerland)

ZHEJIANG XINHUA PHARMACEUTICAL CO., LTD.: Tel:+86-576-85588383; Address: Linhai Zone, Linhai, Zhejiang, China

EasternChem Company Limited: Tel:86-510-85032271-801; Address: Room 1101, YongFeng Building, 27,QingYang Road Wuxi, Jiangsu, 214023 China

Matrix Laboratories Limited: Tel:+91-40-27700363; Address: 1-1-151/1, 4th Floor Sai Ram Towers Alexander Road

10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)- cas no:132539-06-1

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