132539-06-1|10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-Products Supply

10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)- cas no:132539-06-1

Synonyms: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine;Olansek;10H-Thieno(2,3-b)(1,5)benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-;Symbyax;Zyprexa (TN);Olanzapine [USAN:INN];2-methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine;

Identification

Name10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-
CAS132539-06-1
Synonyms2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine;Olansek;10H-Thieno(2,3-b)(1,5)benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-;Symbyax;Zyprexa (TN);Olanzapine [USAN:INN];2-methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine;
Molecular FormulaC₁₇H₂₀N₄S
Molecular Weight312.43

Chemical Properties

Appearanceyellowish crystalline powder
refractive index3.3
storage tempStore in original container in a cool dark place.

Safety Data

Safety

Human systemic effects. When heated to decomposition it emits toxic vapors of NO_x and SO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	16560ug/kg/12 (16.56mg/kg)	BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	Journal of Clinical Psychiatry. Vol. 60, Pg. 767, 1999.
human	TDLo	oral	43mg/kg/30W-I (43mg/kg)	?	Journal of Clinical Pyschopharmacology. Vol. 19, Pg. 273, 1999.
man	LDLo	oral	7067ug/kg (7.067mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"	Journal of Forensic Sciences. Vol. 41, Pg. 1252, 1998.
man	TDLo	oral	2570ug/kg/12D (2.57mg/kg)	AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC	Journal of Clinical Pyschopharmacology. Vol. 19, Pg. 192, 1999.
women	LDLo	oral	30mg/kg/22W-I (30mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Annals of Pharmacotherpy. Vol. 33, Pg. 787, 1999.
women	TDLo	oral	400ug/kg (0.4mg/kg)	BEHAVIORAL: REGIDITY VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	American Journal of Psychiatry. Vol. 156, Pg. 1835, 1999.
women	TDLo	oral	12mg/kg (12mg/kg)	BEHAVIORAL: COMA CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Annals of Emergency Medicine. Vol. 32, Pg. 275, 1998.
women	TDLo	oral	12mg/kg/60D-I (12mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS	Annals of Internal Medicine. Vol. 131, Pg. 72, 1999.

supplier list

Tianjin Harmony Technology Development Co., Ltd.: Tel:; Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China

Hangzhou Starshine Pharmaceutical Co., LTD: Tel:86-571-8696517; Address: Fengqi East Road, Hangzhou, China.

Changzhou ComWin Fine Chemicals Co.,Ltd.: Tel:; Address: 24th Floor, Jiaye International Commercial Plaza, 99 Yanling West Road, Changzhou, Jiangsu, China

Chuming Pharmaceutical Limited: Tel:; Address: 9th Fl.,Garden Building, Jiuzhou Ave. No.1083, Zhuhai,China

SINOCHEM NINGBO LTD.: Tel:86-574-87260209 87348868; Address: 21 Jiangxia St.,Ningbo 315000 .Zhejiang. China

Luna Chemicals Co.,Ltd.: Tel:; Address: 1502-1503,No.310 North Zhong Shan Rd., Hangzhou,China

Hangzhou Sida Organic Chemical Co., Ltd.: Tel:+86-571-88212350; Address: Room 301, Building Auxiliary, Longdu Mansion,No.376.Tianmushan Road,Hangzhou 310012 China

Oasischem International: Tel:; Address: Hefei New & High Technology Development Zone

Sunasia Co., Ltd.: Tel:; Address: Suite 1503, 15Fl., Huijin Mansion, No. 77 He Yi Road, Ningbo 315000 China

CIDIC Co.,Ltd.: Tel:; Address: 15/F, HODO International Plaza, 531 Zhongshan Road, Wuxi, China

Aliapharm: Tel:+49 69 971412-0; Address: AliaPharm GmbH Frankfurt Niedenau 49 60325 Frankfurt / Main

Changzhou Leo Chemical Co.,Ltd.: Tel:; Address: NO. 538 XINQING ROAD, XINZHA TOWN, ZHONGLOU DISTRICT, CHANGZHOU, JIANGSU, CHINA

Beijing Lunarsun Pharmaceutical Co.Ltd.: Tel:086-10-81760039 80771377 80771378 80771379 81760170 81760171 81760172; Address: C1-802, Yangguangguangchang, Anli Road No.68 ,Chaoyang District , 100101 , Beijing , P.R.China

Levachem Co. Ltd.: Tel:86-25-83247442 / 443 / 445 / 446 / 447; Address: 2112, SuNing Universal Mansion, 188 Guangzhou Road, Nanjing-210024, China

EasternChem Company Limited: Tel:86-510-85032271-801; Address: Room 1101, YongFeng Building, 27,QingYang Road Wuxi, Jiangsu, 214023 China

10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)- cas no:132539-06-1

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