13292-46-1|RifampicinProducts Supply - Chemical intermediates Network

Rifampicin cas no:13292-46-1

Synonyms: 3-[[(4-methyl-1-piperazinyl)imino]methyl]-rifamycin;3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV;5,6,9,17,19,21-Hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-(N-(4-methyl-1-piperazinyl)formimidoyl)-2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione 21-acetate;8-(4-Methylpiperazinyliminomethyl) rifamycin SV;

Identification

NameRifampicin
CAS13292-46-1
Synonyms3-[[(4-methyl-1-piperazinyl)imino]methyl]-rifamycin;3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV;5,6,9,17,19,21-Hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-(N-(4-methyl-1-piperazinyl)formimidoyl)-2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione 21-acetate;8-(4-Methylpiperazinyliminomethyl) rifamycin SV;
EINECS(EC#)236-312-0
Molecular FormulaC₄₃H₅₈N₄O₁₂
Molecular Weight822.95

Chemical Properties

AppearanceRed to orange crystalline solid
refractive index1.613
storage temp2-8°C

Safety Data

Hazard Xn:Harmful
Risk R22;R36/37/38
Safety

Hazard Codes:? Harmful Xn, Irritant Xi
Risk Statements: 22-36/37/38-36/38
?R22:Harmful if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R36/38:Irritating to eyes and skin.
Safety Statements: 26-36-37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.?
S37/39:Wear suitable gloves and eye/face protection.

HS Code 29419000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intraperitoneal	639mg/kg (639mg/kg)	?	Antibiotica et Chemotherapia Vol. 16, Pg. 316, 1970.
human	TDLo	oral	180mg/kg (180mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE SENSE ORGANS AND SPECIAL SENSES: IRITIS: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	British Medical Journal. Vol. 2, Pg. 1189, 1977.
man	LDLo	oral	857mg/kg (857mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	JAMA, Journal of the American Medical Association. Vol. 240, Pg. 2283, 1978.
man	TDLo	oral	13mg/kg/2D (13mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	British Medical Journal. Vol. 1, Pg. 199, 1976.
man	TDLo	oral	814mg/kg/15W- (814mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: HEMATURIA	American Journal of Kidney Diseases. Vol. 32, Pg. 533, 1998.
mouse	LD50	intraperitoneal	416mg/kg (416mg/kg)	?	Chemotherapia. Vol. 12, Pg. 155, 1967.
mouse	LD50	intravenous	260mg/kg (260mg/kg)	?	Antibiotica et Chemotherapia Vol. 16, Pg. 316, 1970.
mouse	LD50	oral	500mg/kg (500mg/kg)	?	Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. Vol. 269, Pg. 2147, 1969.
mouse	LD50	subcutaneous	621mg/kg (621mg/kg)	?	Japanese Journal of Antibiotics. Vol. 23, Pg. 242, 1970.
rabbit	LD50	oral	2120mg/kg (2120mg/kg)	?	Antibiotica et Chemotherapia Vol. 16, Pg. 316, 1970.
rat	LD50	intraperitoneal	511mg/kg (511mg/kg)	?	Japanese Journal of Antibiotics. Vol. 23, Pg. 257, 1970.
rat	LD50	oral	1570mg/kg (1570mg/kg)	?	Japanese Journal of Antibiotics. Vol. 23, Pg. 257, 1970.
rat	LD50	subcutaneous	534mg/kg (534mg/kg)	?	Japanese Journal of Antibiotics. Vol. 23, Pg. 242, 1970.
women	TDLo	oral	315mg/kg/5W-I (315mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Journal of the American Academy of Dermatology. Vol. 17, Pg. 303, 1987.
women	TDLo	oral	504mg/kg/42D- (504mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA BLOOD: APLASTIC ANEMIA	American Journal of Medicine. Vol. 87, Pg. 459, 1989.
women	TDLo	oral	744mg/kg/9W-I (744mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	American Journal of Kidney Diseases. Vol. 31, Pg. 108, 1998.

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Synthiko Industries: Tel:+91-(22)-26342508, 26379741; Address: Jay House,13 / 14, Andheri - Kurla Road, Andheri (E), Mumbai, Maharashtra 400069,

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Varda Biotech Pvt. Ltd.: Tel:+91-(22)-6693 5686; Address: #110 & 111 Kartik Complex, New Link Road, Andheri (W), Mumbai, Maharashtra 400 053,

Rifampicin cas no:13292-46-1

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