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1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide cas no:133-06-2

Synonyms: Captan; N-Trichloromethylthio-4-cyclohexene-1,2-dicarboximide

Identification
Name1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide
CAS133-06-2
SynonymsCaptan; N-Trichloromethylthio-4-cyclohexene-1,2-dicarboximide
EINECS(EC#)205-087-0
Molecular FormulaC9H8Cl3NO2S
Molecular Weight300.59
Chemical Properties
Appearancesolid
refractive index1.636
storage temp0-6°C
Safety Data

Hazard T:Toxic
Risk R23;R40;R41;R43;R50
Safety

Safety Information of?Captan (CAS NO.133-06-2):
Hazard Codes: N ,T ,Xn ,F
Risk Statements: 23-40-41-43-50-36-20/21/22-11
R23: Toxic by inhalation.?
R40: Limited evidence of a carcinogenic effect.
R41: Risk of serious damage to the eyes.?
R43: May cause sensitization by skin contact.?
R50: Very toxic to aquatic organisms.?
R36: Irritating to eyes.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.?
R11: Highly flammable.
Safety Statements: 26-29-36/37/39-45-61?
S26:?In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S29: Do not empty into drains.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 3077/9099
RTECS: GW5075000
Poison by intraperitoneal route. Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion and inhalation routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic and neoplastigenic data. Human mutation data reported. When heated to decomposition it emits toxic fumes of Cl?, SOx, and NOx.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - domestic LDLo unreported > 100mg/kg (100mg/kg) ? Pesticide Manual. Vol. 9, Pg. 119, 1991.
human LDLo oral 1071mg/kg (1071mg/kg) ? "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 151, 1969.
mouse LC50 inhalation 4500mg/m3/2H (4500mg/m3) ? Toxicology and Applied Pharmacology. Vol. 45, Pg. 320, 1978.
mouse LD50 intraperitoneal 30mg/kg (30mg/kg) ? Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe A: Medizinische Mikrobiologie und Parasitologie. Vol. 234, Pg. 110, 1976.
mouse LD50 oral 7gm/kg (7000mg/kg) ? Toxicology and Applied Pharmacology. Vol. 45, Pg. 320, 1978.
mouse LD50 unreported 138mg/kg (138mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(10), Pg. 24, 1973.
rabbit LD50 unreported 740mg/kg (740mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(10), Pg. 24, 1973.
rat LC50 inhalation > 5700mg/m3/2H (5700mg/m3) ? Toxicology and Applied Pharmacology. Vol. 45, Pg. 320, 1978.
rat LD50 oral 9gm/kg (9000mg/kg) ? Farm Chemicals Handbook. Vol. -, Pg. C59, 1991.
rat LD50 skin > 5gm/kg (5000mg/kg) ? Fundamental and Applied Toxicology. Vol. 7, Pg. 299, 1986.
rat LD50 unreported 2650mg/kg (2650mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(10), Pg. 24, 1973.
rat LDLo intraperitoneal 25mg/kg (25mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: SLEEP

BEHAVIORAL: FLUID INTAKE
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 168, Pg. 1173, 1974.

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