2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide cas no:133-67-5
Synonyms: 3-Dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide;3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide;3-Dichloromethylhydrochlorothiazide;6-Chloro-3-(dichloromethyl)-3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide;6-Chloro-3-dichloromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine1,1-dioxide;Achletin;Carvacron;Diurese;Diuroral;Esmarin;Fluitran;Flurese;Gangesol;Hydrotrichlorothiazide;Intromene;Kubacron;Metahydrin;Metatensin;NSC 61560;Nakva;Naqua;Naquasone;Naquival;Salirom;Tachionin;Tolcasone;Trichlormetazid;Triflumen;
Name2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
CAS133-67-5
Synonyms3-Dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide;3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide;3-Dichloromethylhydrochlorothiazide;6-Chloro-3-(dichloromethyl)-3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide;6-Chloro-3-dichloromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine1,1-dioxide;Achletin;Carvacron;Diurese;Diuroral;Esmarin;Fluitran;Flurese;Gangesol;Hydrotrichlorothiazide;Intromene;Kubacron;Metahydrin;Metatensin;NSC 61560;Nakva;Naqua;Naquasone;Naquival;Salirom;Tachionin;Tolcasone;Trichlormetazid;Triflumen;
EINECS(EC#)205-118-8
Molecular FormulaC8H8Cl3N3O4S2
Molecular Weight380.64
refractive index1.625
Hazard Xn: Harmful;
Risk R42/43
Safety
Moderately toxic by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. Used as a diuretic and antihypertensive drug. When heated to decomposition it emits very toxic fumes such as SOx, Cl− and NOx.
Hazard Codes 
Xn
Risk Statements 42/43
R42/43: Hydrotrichlorothiazide (CAS NO.133-67-5) may cause sensitization by inhalation and skin contact.
Safety Statements 36
S36:Wear suitable protective clothing.
WGK Germany 2
RTECS DK8925000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| man |
TDLo |
oral |
3320ug/kg/7W- (3.32mg/kg) |
BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" |
Kyorin Igakkai Zasshi. Journal of the Kyorin Medical Society. Vol. 13, Pg. 199, 1982. |
| mouse |
LD50 |
intraperitoneal |
540mg/kg (540mg/kg) |
|
Farmaco, Edizione Scientifica. Vol. 16, Pg. 647, 1961. |
| mouse |
LD50 |
intravenous |
750mg/kg (750mg/kg) |
|
"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 119, 1969. |
| mouse |
LD50 |
oral |
2600mg/kg (2600mg/kg) |
|
Farmaco, Edizione Scientifica. Vol. 16, Pg. 647, 1961. |
| rat |
LD50 |
intravenous |
920mg/kg (920mg/kg) |
|
"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 119, 1969. |
| rat |
LD50 |
oral |
5600mg/kg (5600mg/kg) |
|
Journal of Pharmacology and Experimental Therapeutics. Vol. 140, Pg. 249, 1963. |
