b-D-Glucopyranosiduronic acid,(R)-cyanophenylmethyl cas no:1332-94-1

Nameb-D-Glucopyranosiduronic acid,(R)-cyanophenylmethyl
CAS1332-94-1
Synonymsb-D-Glucopyranosiduronic acid,cyanophenylmethyl, (R)-; Laetrile; Mandelonitrile b-glucuronide; NSC 103055; Vitamin B17
Molecular FormulaC14H15 N O7
Molecular Weight309.30

refractive index1.634

Safety

Human poison by ingestion. Experimental poison by intraperitoneal route. Human systemic effects by ingestion and multiple routes: central nervous system and gastrointestinal changes. Mutation data reported. A controversial treatment for cancer. When heated to decomposition it emits toxic fumes of NO_x and CN⁻. See also NITRILES.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	1286mg/kg/24W (1286mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: MUSCLE WEAKNESS	JAMA, Journal of the American Medical Association. Vol. 238, Pg. 1361, 1977.
rabbit	LD50	intravenous	687uL/kg (0.687mL/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: ATAXIA	United States Patent Document. Vol. #4337760,
rat	LDLo	intraperitoneal	250mg/kg (250mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION LUNGS, THORAX, OR RESPIRATION: CYANOSIS	JAMA, Journal of the American Medical Association. Vol. 242, Pg. 169, 1979.
women	LDLo	oral	198mg/kg (198mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" LUNGS, THORAX, OR RESPIRATION: DYSPNEA	JAMA, Journal of the American Medical Association. Vol. 239, Pg. 1532, 1978.
women	TDLo	multiple routes	4170mg/kg/8W (4170mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Cancer Treatment Reports. Vol. 62, Pg. 169, 1978.
women	TDLo	oral	60mg/kg (60mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LIVER: FATTY LIVER DEGERATION	Southern Medical Journal. Vol. 79, Pg. 259, 1986.