1-Aminonaphthalene cas no:134-32-7

Name1-Aminonaphthalene
CAS134-32-7
Synonyms1-Naphthylamine(8CI);1-Naphthalamine;C.I. 37265;C.I. Azoic DiazoComponent 114;Fast Garnet Base B;Naphthalen-1-ylamine;Naphthalidam;Naphthalidine;a-Aminonaphthalene;alfa-Naftyloamina;
EINECS(EC#)205-138-7
Molecular FormulaC₁₀H₉N
Molecular Weight143.19

AppearanceA crystalline solid or a solid dissolved in a liquid.
refractive index1.6703
storage temp2-8°C

Hazardclass6.1(b)

Hazard Toxic, especially if containing the β isomer; a carcinogen (OSHA).
Risk R34
Safety Confirmed carcinogen with experimental tumorigenic data. Along with β-naphthylamine and benzidine, it has been incriminated as a cause of urinary bladder cancer. Poison by subcutaneous and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. Combustible when exposed to heat or flame. Incompatible with nitrous acid. To fight fire, use dry chemical, CO2, mist, spray. When heated to decomposition it emits toxic fumes of NOx. See also 2-NAPHTHYLAMINE and AROMATIC AMINES.Analytical Methods:   For occupational chemical analysis use NIOSH: Naphthylamines, 5518.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

QM1400000

CHEMICAL NAME :

1-Naphthylamine

CAS REGISTRY NUMBER :

134-32-7

BEILSTEIN REFERENCE NO. :

0386133

LAST UPDATED :

199710

DATA ITEMS CITED :

58

MOLECULAR FORMULA :

C10-H9-N

MOLECULAR WEIGHT :

143.20

WISWESSER LINE NOTATION :

L66J BZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

96 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Behavioral - tremor Behavioral - muscle weakness

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

4 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1300 mg/kg/13W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia

TYPE OF TEST :

Morphological transformation

TYPE OF TEST :

DNA damage

TYPE OF TEST :

DNA damage

TYPE OF TEST :

DNA inhibition

TYPE OF TEST :

Sister chromatid exchange

TYPE OF TEST :

Sperm Morphology

MUTATION DATA

TEST SYSTEM :

Mammal - dog

REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 49,125,1983 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,87,1974 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,87,1974 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,260,1987 TOXICOLOGY REVIEW KHZHAZ Khimiya i Zhizn. Chemistry and Life. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1965- Volume(issue)/page/year: 12(2),85,1976 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:skin-HUMAN CARCINOGEN, NO ASSIGNED TWA DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,24,1973 OSHA PEL (Construc):see CFR 29,1926.1104 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA-cancer suspect agent CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1004,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-SWEDEN;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO alpha-NAPHTHYLAMINE-air:CA use 29 CFR 1910.1004 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84304 No. of Facilities: 66 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 610 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84304 No. of Facilities: 268 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 2132 (estimated) No. of Female Employees: 1796 (estimated)