(-)-Lobeline Hydrochloride cas no:134-63-4

Name(-)-Lobeline Hydrochloride
CAS134-63-4
SynonymsLobeline hydrochloride; 2-(6-(2-hydroxy-2-phenethyl)-1-methyl-2-piperidyl)acetophenone hydrochloride; Lobeline HCL
EINECS(EC#)205-150-2
Molecular FormulaC22H27NO2?HCl
Molecular Weight373.92

AppearanceWhite to off-white solid
refractive index-57.5 ° (C=1, H2O)

Hazardclass6.1(b)

Hazard T:Toxic;
Risk R23/25

CHEMICAL IDENTIFICATION

RTECS NUMBER :

OJ8490100

CHEMICAL NAME :

Lobeline, hydrochloride

CAS REGISTRY NUMBER :

134-63-4

LAST UPDATED :

198706

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C22-H27-N-O2.Cl-H

MOLECULAR WEIGHT :

373.96

WISWESSER LINE NOTATION :

T6NTJ A1 B1YQR& F1VR &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

39900 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,913,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

87500 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,913,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

7800 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,913,1982

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Parenteral

SPECIES OBSERVED :

Amphibian - frog

DOSE/DURATION :

150 mg/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold

REFERENCE :

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 163,279,1931