Benzenemethanol, a-[(1R)-1-(methylamino)ethyl]-,hydrochloride (1:1), (aS)-rel- cas no:134-71-4

Synonyms: Benzenemethanol,a-[(1R)-1-(methylamino)ethyl]-,hydrochloride, (aS)-rel-(9CI);Benzenemethanol, a-[1-(methylamino)ethyl]-,hydrochloride, (R*,S*)-;Ephetonin;Ephetonine;Racephedrine Hydrochloride;dl-Ephedrinehydrochloride;

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Identification
Chemical Properties
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Safety Data
Toxicity

Identification

NameBenzenemethanol, a-[(1R)-1-(methylamino)ethyl]-,hydrochloride (1:1), (aS)-rel-
CAS134-71-4
SynonymsBenzenemethanol,a-[(1R)-1-(methylamino)ethyl]-,hydrochloride, (aS)-rel-(9CI);Benzenemethanol, a-[1-(methylamino)ethyl]-,hydrochloride, (R*,S*)-;Ephetonin;Ephetonine;Racephedrine Hydrochloride;dl-Ephedrinehydrochloride;
EINECS(EC#)205-153-9
Molecular FormulaC10H15 N O . Cl H
Molecular Weight201.72

Chemical Properties

AppearanceWhite solid

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xn: Harmful;
Risk R22;R36/37/38
Safety

Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects: cardiac changes, nausea or vomiting, sweating. When heated to decomposition it emits very toxic fumes of HCl and NO_x. See also EPHEDRINE.Safety information of DL-Ephedrine hydrochloride (CAS NO.134-71-4):
Hazard Codes Harmful Xn
Risk Statements 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR 1544
WGK Germany 3
RTECS KB1750000
HazardClass 6.1(b)
PackingGroup III

Toxicity

1.	orl-wmn TDLo:1 mg/kg:CAR,GIT,SKN	JPETAB Journal of Pharmacology and Experimental Therapeutics. 33 (1928),237.
2.	orl-man TDLo:1429 µg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 33 (1928),237.
3.	scu-rat LD50:350 mg/kg	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 169 (1933),114.
4.	orl-mus LD50:700 mg/kg	JMCMAR Journal of Medicinal Chemistry. 9 (1966),966.
5.	ipr-mus LD50:254 mg/kg	PHARAT Pharmazie. 24 (1969),775.
6.	scu-mus LD50:520 mg/kg	NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. 55 (1959),653.
7.	ivn-mus LD50:135 mg/kg	JMCMAR Journal of Medicinal Chemistry. 9 (1966),966.
8.	ivn-rbt LDLo:60 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 36 (1929),363.

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