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PHENAZOPYRIDINE HYDROCHLORIDE cas no:136-40-3

Synonyms: BISTERIL ; MALLOPHENE ; 3-PHENYLAZO-2,6-DIAMINOPYRIDINE HYDROCHLORIDE ; 3-PHENYLAZO-2,6-DIAMINOPYRIDINE MONOHYDROCHLORIDE ; 3-(PHENYLAZO)-2,6-PYRIDINEDIAMINE, MONOHYDROCHLORIDE ; 3-BENZENEAZO-2,6-DIAMINOPYRIDINE MONOHYDROCHLORIDE ; 2,6-DIAMINO-3-[PHENYLAZO]PYRIDINE HYDROCHLORIDE ; 2,6-DIAMINO-3-(PHENYLAZO)PYRIDINE MONOHYDROCHLORIDE ; PHENYLAZODIAMINOPYRIDINE HYDROCHLORIDE ; PHENAZODINE ; PHENAZOPYRIDINE HCL ; PYRIDACIL;

Identification
NamePHENAZOPYRIDINE HYDROCHLORIDE
CAS136-40-3
SynonymsBISTERIL ; MALLOPHENE ; 3-PHENYLAZO-2,6-DIAMINOPYRIDINE HYDROCHLORIDE ; 3-PHENYLAZO-2,6-DIAMINOPYRIDINE MONOHYDROCHLORIDE ; 3-(PHENYLAZO)-2,6-PYRIDINEDIAMINE, MONOHYDROCHLORIDE ; 3-BENZENEAZO-2,6-DIAMINOPYRIDINE MONOHYDROCHLORIDE ; 2,6-DIAMINO-3-[PHENYLAZO]PYRIDINE HYDROCHLORIDE ; 2,6-DIAMINO-3-(PHENYLAZO)PYRIDINE MONOHYDROCHLORIDE ; PHENYLAZODIAMINOPYRIDINE HYDROCHLORIDE ; PHENAZODINE ; PHENAZOPYRIDINE HCL ; PYRIDACIL;
EINECS(EC#)205-243-8
Molecular FormulaC11H11N5?HCl;C11H12ClN5
Molecular Weight249.7
Chemical Properties
Appearancebrick-red crystals
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Safety Data

Hazard Xn:Harmful;
Risk R22;R36/37/38;R40
Safety

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. A poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Human systemic effects by ingestion: somnolence, cyanosis, diarrhea, nausea or vomiting, anuria or decreased urine volume, normocytic anemia, methemoglobinemia-carboxyhemoglobinemia, dehydration, changes in blood sodium levels. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Hazard Codes:?HarmfulXn,CorrosiveC
Risk Statements: 22-36/37/38-40-34
R22: Harmful if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R34: Causes burns.?
R40: Limited evidence of a carcinogenic effect.
Safety Statements of Phenazopyridine hydrochloride (CAS NO.136-40-3): 26-36/37-45-36/37/39-27?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37: Wear suitable protective clothing and gloves.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S27: Take off immediately all contaminated clothing.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 35mg/kg (35mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
KIDNEY, URETER, AND BLADDER: HEMATURIA
BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
American Journal of Diseases of Children. Vol. 117, Pg. 369, 1969.
?
child TDLo oral 125mg/kg (125mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA
Clinical Pediatrics Vol. 10, Pg. 537, 1971.
?
child TDLo oral 400mg/kg (400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
American Journal of Diseases of Children. Vol. 110, Pg. 105, 1965.
?
man TDLo oral 86mg/kg/10D-I (86mg/kg) SPINAL CORD: INFLAMMATORY CHANGES Annals of Internal Medicine. Vol. 106, Pg. 164, 1987.
man TDLo oral 114mg/kg (114mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Human Toxicology. Vol. 2, Pg. 539, 1983.
?
mouse LD50 intravenous 180mg/kg (180mg/kg) ? U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04014,
rat LD50 oral 472mg/kg (472mg/kg) ? Toxicology and Applied Pharmacology. Vol. 1, Pg. 42, 1959.
rat LDLo intraperitoneal 200mg/kg (200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
Journal of Pharmacology and Experimental Therapeutics. Vol. 51, Pg. 200, 1934.
women TDLo oral 34mg/kg (34mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Annals of Internal Medicine. Vol. 72, Pg. 89, 1970.
?
women TDLo oral 140mg/kg (140mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING
BLOOD: NORMOCYTIC ANEMIA
Canadian Medical Association Journal. Vol. 91, Pg. 756, 1964.

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