136-47-0|tetracaine hydrochloride uspProducts Supply

tetracaine hydrochloride usp cas no:136-47-0

Synonyms: Tetracaine HCl; 2-dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride; 4-(butylamino)-Benzoic acid, 2-(dimethylamino)ethyl ester, monohydrochloride; p-butylaminobenzoyl-2-dimethylaminoethanol hydrochloride; Amethocaine hydrochloride; Anethaine; Butethanol; Curtacain; Decicain; Gingicain M; Menonasal; Pantocaine; Pontocaine hydrochloride; Tetracaine hydrochloride; Tonexol; Tetracaine?HCL

Identification

Nametetracaine hydrochloride usp
CAS136-47-0
SynonymsTetracaine HCl; 2-dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride; 4-(butylamino)-Benzoic acid, 2-(dimethylamino)ethyl ester, monohydrochloride; p-butylaminobenzoyl-2-dimethylaminoethanol hydrochloride; Amethocaine hydrochloride; Anethaine; Butethanol; Curtacain; Decicain; Gingicain M; Menonasal; Pantocaine; Pontocaine hydrochloride; Tetracaine hydrochloride; Tonexol; Tetracaine?HCL
EINECS(EC#)205-248-5
Molecular FormulaC15H24N2O2?HCl
Molecular Weight264.36326

Chemical Properties

AppearanceWhite or off white crystalline powder
storage tempKeep tightly closed.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1

Safety Data

Hazard T:Toxic
Risk R25;R36;R43
Safety

Hazard Codes:? Toxic T
Risk Statements: 25-36-42/43?
R25: Toxic if swallowed.?
R36: Irritating to eyes.?
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 26-45-36/37/39-22-53?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S22: Do not breathe dust.?
S53: Avoid exposure - obtain special instructions before use.
RIDADR: 2811
RTECS: DG4900000
Poison by ingestion, intraperitoneal, intravenous, intraspinal, and subcutaneous routes. An eye irritant. When heated to decomposition it emits very toxic fumes of HCl and NO_x. An FDA over-the-counter drug used as a local anesthetic.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intravenous	4mg/kg (4mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 739, 1957.
guinea pig	LD50	subcutaneous	19500ug/kg (19.5mg/kg)	?	Quarterly Journal of Pharmacy & Pharmacology. Vol. 20, Pg. 380, 1947.
mouse	LD50	intraperitoneal	23mg/kg (23mg/kg)	?	Archiv der Pharmazie Vol. 321, Pg. 115, 1988.
mouse	LD50	intravenous	6400ug/kg (6.4mg/kg)	?	Drugs in Japan Vol. -, Pg. 815, 1995.
mouse	LD50	oral	160mg/kg (160mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 413, 1975.
mouse	LD50	subcutaneous	25mg/kg (25mg/kg)	?	Pharmacology and Toxicology. English translation of FATOAO. Vol. 22, Pg. 138, 1959.
rabbit	LD50	intratracheal	4400ug/kg (4.4mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 87, 1961.
rabbit	LD50	intravenous	2150ug/kg (2.15mg/kg)	?	Drugs in Japan Vol. 6, Pg. 490, 1982.
rabbit	LD50	subcutaneous	15mg/kg (15mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 388, 1948.
rabbit	LDLo	intraspinal	5mg/kg (5mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 57, Pg. 221, 1936.
rat	LD50	intraperitoneal	23500ug/kg (23.5mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 413, 1975.
rat	LD50	intravenous	4500ug/kg (4.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 413, 1975.
rat	LD50	subcutaneous	24mg/kg (24mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 413, 1975.

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tetracaine hydrochloride usp cas no:136-47-0

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