13614-98-7|minocycline hydrochlorideProducts Supply

minocycline hydrochloride cas no:13614-98-7

Synonyms: Minocycline HCL; Minocyclin HCl; (4s-(4alpha,4aalpha,5aalpha,12aalpha))-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride

Identification

Nameminocycline hydrochloride
CAS13614-98-7
SynonymsMinocycline HCL; Minocyclin HCl; (4s-(4alpha,4aalpha,5aalpha,12aalpha))-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride
EINECS(EC#)237-099-7
Molecular FormulaC23H27N3O7?HCl
Molecular Weight493.94

Chemical Properties

Appearancecrystalline yellow
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xi:Irritant;
Risk R36/37/38
Safety

Hazard Codes:? Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
RIDADR: 3249
WGK Germany: 3
RTECS: QI7630500
HazardClass: 6.1(b)
PackingGroup：? III
Risk Statements：?Irritating to the eyes；Irritating to the respiratory system；Irritating to the skin
Safety Statements：?Wear suitable protective clothing
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and parenteral routes. Human systemic effects: dermatitis, eye effects, increased body temperature. When heated to decomposition it emits toxic fumes of NO_x and HCl.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	14286ug/kg/10 (14.286mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Archives of Internal Medicine. Vol. 154, Pg. 1633, 1994.
man	TDLo	intravenous	2857ug/kg (2.857mg/kg)	LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Internal Medicine. Vol. 33, Pg. 177, 1994.
man	TDLo	oral	11429ug/kg/4D (11.429mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Archives of Dermatology. Vol. 123, Pg. 18, 1987.
man	TDLo	oral	3893mg/kg/4Y- (3893mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Archives of Dermatology. Vol. 122, Pg. 17, 1986.
mouse	LD50	intraperitoneal	299mg/kg (299mg/kg)	?	Drugs in Japan Vol. 6, Pg. 811, 1982.
mouse	LD50	intravenous	154mg/kg (154mg/kg)	?	Drugs in Japan Vol. 6, Pg. 811, 1982.
mouse	LD50	oral	3600mg/kg (3600mg/kg)	?	Drugs in Japan Vol. 6, Pg. 811, 1982.
mouse	LD50	subcutaneous	2290mg/kg (2290mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990.
mouse	LDLo	parenteral	620mg/kg (620mg/kg)	?	Chemotherapy Vol. 24, Pg. 17, 1978.
rat	LD50	intraperitoneal	331mg/kg (331mg/kg)	?	Drugs in Japan Vol. 6, Pg. 811, 1982.
rat	LD50	intravenous	164mg/kg (164mg/kg)	?	Drugs in Japan Vol. 6, Pg. 811, 1982.
rat	LD50	oral	2380mg/kg (2380mg/kg)	?	Drugs in Japan Vol. 6, Pg. 811, 1982.
rat	LD50	subcutaneous	1700mg/kg (1700mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990.
women	TDLo	oral	42mg/kg/3W-I (42mg/kg)	BLOOD: AGRANULOCYTOSIS BLOOD: OTHER CHANGES MUSCULOSKELETAL: JOINTS	Archives of Internal Medicine. Vol. 154, Pg. 1983, 1994.

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Saniver Limited: Tel:; Address: 805 Harbour Centre, Tower 2, 8 Hok Cheung St., Hunghom, Kowloon, Hong Kong.

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minocycline hydrochloride cas no:13614-98-7

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