1H-2,5-Benzoxazocine,3,4,5,6-tetrahydro-5-methyl-1-phenyl- cas no:13669-70-0
Synonyms: 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine;Fenazoxine;Nefopam;
Name1H-2,5-Benzoxazocine,3,4,5,6-tetrahydro-5-methyl-1-phenyl-
CAS13669-70-0
Synonyms3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine;Fenazoxine;Nefopam;
EINECS(EC#)237-148-2
Molecular FormulaC17H19NO
Molecular Weight253.37
refractive index1.563
Safety
Poison by ingestion, intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion: hallucinations, distorted perceptions, excitement, motor activity changes, increased pulse rate without blood pressure fall and heart rate changes. When heated to decomposition it emits toxic fumes of NOx.
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orl-wmn TDLo:15 mg/kg:CNS,CVS
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BMJOAE British Medical Journal. 283 (1981),1508. |
| 2. |
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orl-man TDLo:17 mg/kg:CNS,CVS
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BMJOAE British Medical Journal. 283 (1981),1508. |
| 3. |
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orl-rat LD50:178 mg/kg
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DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249. |
| 4. |
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ivn-rat LD50:28 mg/kg
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DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249. |
| 5. |
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ims-rat LD50:57 mg/kg
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DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249. |
| 6. |
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orl-mus LD50:119 mg/kg
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DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249. |
| 7. |
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ipr-mus LD50:50 mg/kg
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DDEVD6 Drug Development and Evaluation. 3 (1979),10. |
| 8. |
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ivn-mus LD50:45 mg/kg
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DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249. |
| 9. |
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ims-mus LD50:53 mg/kg
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DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249. |
| 10. |
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