Prostan-1-oic acid,16,16-difluoro-11-hydroxy-9,15-dioxo-, (11a)- cas no:136790-76-6
Synonyms: (-)-7-((2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta(b)pyran-5-yl)heptanoic acid;Amitiza;7-[(1R,4R,6R,9R)-4-(1,1-Difluoropentyl)-4-hydroxy-8-oxo-5-oxabicyclo[4.3.0]non-9-yl]heptanoic acid;
NameProstan-1-oic acid,16,16-difluoro-11-hydroxy-9,15-dioxo-, (11a)-
CAS136790-76-6
Synonyms(-)-7-((2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta(b)pyran-5-yl)heptanoic acid;Amitiza;7-[(1R,4R,6R,9R)-4-(1,1-Difluoropentyl)-4-hydroxy-8-oxo-5-oxabicyclo[4.3.0]non-9-yl]heptanoic acid;
Molecular FormulaC20H32F2O5
Molecular Weight390.461886
Appearancewhite, odorless crystals or crystalline powder
Safety
In clinical trials, the most common adverse event was nausea (31%). Other adverse events (≥5% of patients) included diarrhea (13%), headache (13%), abdominal distention (7%), abdominal pain (7%), flatulence (6%), sinusitis (5%) and vomiting (5%).
