child |
TDLo |
oral |
21mg/kg (21mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Journal of Toxicology, Clinical Toxicology. Vol. 30, Pg. 413, 1992. |
child |
TDLo |
oral |
300mg/kg/5D-I (300mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION |
Pediatric Emergency Care. Vol. 10, Pg. 344, 1994. |
guinea pig |
LD50 |
subcutaneous |
120mg/kg (120mg/kg) |
? |
Farmaco, Edizione Scientifica. Vol. 10, Pg. 883, 1955. |
guinea pig |
LDLo |
intravenous |
65mg/kg (65mg/kg) |
? |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 130, Pg. 235, 1961. |
human |
TDLo |
intravenous |
23mg/kg (23mg/kg) |
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Archiv fuer Toxikologie. Vol. 28, Pg. 72, 1971. |
man |
TDLo |
intravenous |
1700ug/kg/2M- (1.7mg/kg) |
BEHAVIORAL: COMA
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
CARDIAC: PULSE RATE |
American Journal of Emergency Medicine. Vol. 4, Pg. 143, 1986. |
man |
TDLo |
intravenous |
8643ug/kg/4H- (8.643mg/kg) |
BEHAVIORAL: TOXIC PSYCHOSIS |
Annals of Internal Medicine. Vol. 97, Pg. 149, 1982. |
mouse |
LD50 |
intraperitoneal |
102mg/kg (102mg/kg) |
PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC
BEHAVIORAL: ATAXIA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Journal of Medicinal Chemistry. Vol. 24, Pg. 1059, 1981. |
mouse |
LD50 |
intravenous |
20mg/kg (20mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION |
Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 269, 1958. |
mouse |
LD50 |
oral |
220mg/kg (220mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: REGIDITY
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 1275, 1966. |
mouse |
LD50 |
subcutaneous |
238mg/kg (238mg/kg) |
? |
Journal of Medicinal Chemistry. Vol. 28, Pg. 714, 1985. |
rabbit |
LDLo |
intravenous |
41mg/kg (41mg/kg) |
? |
Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972. |
rat |
LD50 |
intraperitoneal |
133mg/kg (133mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 243, Pg. 97, 1980. |
rat |
LD50 |
intravenous |
18mg/kg (18mg/kg) |
? |
United States Patent Document. Vol. #5264432, |
rat |
LD50 |
oral |
317mg/kg (317mg/kg) |
? |
Bollettino Chimico Farmaceutico. Vol. 110, Pg. 330, 1971. |
rat |
LD50 |
subcutaneous |
335mg/kg (335mg/kg) |
? |
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 188, 1974. |
rat |
LD50 |
unreported |
39400ug/kg (39.4mg/kg) |
? |
Farmakologiya i Toksikologiya Vol. 54(3), Pg. 32, 1991. |
women |
TDLo |
intraspinal |
1mL/kg (1mL/kg) |
BEHAVIORAL: EUPHORIA
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" |
Journal of Clinical Pyschopharmacology. Vol. 10, Pg. 442, 1990. |
women |
TDLo |
intravenous |
16mg/kg (16mg/kg) |
CARDIAC: CHANGE IN RATE
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
European Journal of Clinical Pharmacology. Vol. 22, Pg. 129, 1982. |
women |
TDLo |
oral |
39mg/kg (39mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: EXCITEMENT
CARDIAC: CHANGE IN RATE |
New England Journal of Medicine. Vol. 306, Pg. 381, 1982. |