Dioxopromethazine hydrochloride cas no:13754-56-8
Synonyms: Phenothiazine,10-[2-(dimethylamino)propyl]-, 5,5-dioxide (8CI);9,9-Dioxopromethazine;9,9-Dioxypromethazin;Promethazine 5,5-dioxide;10H-Phenothiazine-10-ethanamine,N,N,a-trimethyl-, 5,5-dioxide;
NameDioxopromethazine hydrochloride
CAS13754-56-8
SynonymsPhenothiazine,10-[2-(dimethylamino)propyl]-, 5,5-dioxide (8CI);9,9-Dioxopromethazine;9,9-Dioxypromethazin;Promethazine 5,5-dioxide;10H-Phenothiazine-10-ethanamine,N,N,a-trimethyl-, 5,5-dioxide;
Molecular FormulaC17H20N2O2S
Molecular Weight316.423
Appearancewhite powder
refractive index1.605
Safety
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NOx, SOx, and HCl.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| guinea pig |
LD50 |
intravenous |
8mg/kg (8mg/kg) |
|
Pharmazie. Vol. 25, Pg. 91, 1970. |
| guinea pig |
LD50 |
oral |
225mg/kg (225mg/kg) |
|
Pharmazie. Vol. 25, Pg. 91, 1970. |
| guinea pig |
LD50 |
subcutaneous |
33mg/kg (33mg/kg) |
|
Pharmazie. Vol. 25, Pg. 91, 1970. |
| mouse |
LD50 |
intraperitoneal |
49mg/kg (49mg/kg) |
|
Pharmazie. Vol. 25, Pg. 91, 1970. |
| mouse |
LD50 |
intravenous |
16mg/kg (16mg/kg) |
|
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 18, Pg. 155, 1983. |
| mouse |
LD50 |
oral |
50mg/kg (50mg/kg) |
|
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 18, Pg. 155, 1983. |
| mouse |
LD50 |
subcutaneous |
96mg/kg (96mg/kg) |
|
Pharmazie. Vol. 25, Pg. 91, 1970. |
| rabbit |
LD50 |
oral |
165mg/kg (165mg/kg) |
|
Pharmazie. Vol. 25, Pg. 91, 1970. |
