Urea,N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso- cas no:13909-09-6

NameUrea,N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-
CAS13909-09-6
SynonymsUrea,1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso- (8CI);ICIG 1110;Me-CCNU;Methyllomustine;Methyl-CCNU;N-(2-Chloroethyl)-N'-(4-methylcyclohexyl)-N-nitrosourea;N'-(4-Methylcyclohexyl)-N-(2-chloroethyl)-N-nitrosourea;Semustine;
Molecular FormulaC₁₀H₁₈ClN₃O₂
Molecular Weight247.72

AppearanceLight yellow powder
refractive index1.51

Hazardclass6.1(a)

Hazard T: Toxic;
Risk R45
Safety

Confirmed human carcinogen producing leukemia. Experimental carcinogenic and tumorigenic data. Poison by ingestion, intraperitoneal, intravenous, and possibly other routes. Mutation data reported. Human systemic effects by ingestion: nausea or vomiting, damage to kidney tubules and glomeruli, and hematuria (blood in the urine). When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x. See also N-NITROSO COMPOUNDS.Safety information of Semustine (CAS NO.13909-09-6):
Hazard Codes  T
Risk Statements 
45 May cause cancer
46 May cause heritable genetic damage
23/24/25 Toxic by inhalation, in contact with skin and if swallowed
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements 
53 Avoid exposure - obtain special instruction before use
22 Do not breathe dust
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39 Wear suitable protective clothing, gloves and eye/face protection
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR  3249
WGK Germany  3
RTECS  YS5000000
HazardClass  6.1(a)
PackingGroup  II

1.		skn-rbt 5 mg/24H rns		TXCYAC    Toxicology. 14 (1979),117.
2.		mmo-sat 100 nmol/plate		JJIND8    JNCI, Journal of the National Cancer Institute. 65 (1980),149.
3.		mma-sat 100 nmol/plate		JJIND8    JNCI, Journal of the National Cancer Institute. 65 (1980),149.
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11.		orl-chd TDLo:37,950&