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Nystatin cas no:1400-61-9

Synonyms: Biofanal;Candio-Hermal;Diastatin;Flagystatin;Fungicidin;L-Nystatin;Moronal (antibiotic);Myconystatin;Mycostatin;MycostatinPastilles;Mykostatyna;Nistatin;Nyotran;Nysfungin;Nystacid;Nystan;Nystavescent;Nystex;Nystop;O-V Statin;Stamycin;

Identification
NameNystatin
CAS1400-61-9
SynonymsBiofanal;Candio-Hermal;Diastatin;Flagystatin;Fungicidin;L-Nystatin;Moronal (antibiotic);Myconystatin;Mycostatin;MycostatinPastilles;Mykostatyna;Nistatin;Nyotran;Nysfungin;Nystacid;Nystan;Nystavescent;Nystex;Nystop;O-V Statin;Stamycin;
EINECS(EC#)215-749-0
Molecular FormulaC47H75NO17
Molecular Weight926.1
Chemical Properties
Appearanceyellow suspension
refractive index1.503
storage temp?20°C
Safety Data

Hazard F, C
Risk R11
Safety Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. Mildly toxic by ingestion. An experimental teratogen. Mutation data reported. An antibiotic. When heated to decomposition it emits toxic fumes of NOx.

Toxicity

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RF5950000
CHEMICAL NAME :
Nystatin
CAS REGISTRY NUMBER :
1400-61-9
LAST UPDATED :
199512
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C46-H83-N-O18
MOLECULAR WEIGHT :
938.30
WISWESSER LINE NOTATION :
T-38-VO D&V GU IU MU OU QU SUTJ C1 D1 EQ F1 WQ A&VQ B&Q F&Q G&Q J&Q L&Q N&Q UO- BT6OTJ CQ DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
24305 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
180 mg/kg/90D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
100 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 33,306,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1053 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 8736 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1053 No. of Facilities: 372 (estimated) No. of Industries: 1 No. of Occupations: 10 No. of Employees: 25202 (estimated) No. of Female Employees: 22859 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9349 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2199 (estimated) No. of Female Employees: 2176 (estimated)

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AFINE CHEMICALS LIMITED
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AFINE CHEMICALS LIMITED
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Struchem Co Ltd
Tel:86-512-63009836
Address: No. 2358 Chang'an Rd, Wujiang City, JiangSu Province, China 215200

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