14008-44-7|4-Piperidinecarboxamide,1-[3-[2-(methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-Products Supply

4-Piperidinecarboxamide,1-[3-[2-(methylsulfonyl)-10H-phenothiazin-10-yl]propyl]- cas no:14008-44-7

Synonyms: Isonipecotamide,1-[3-[2-(methylsulfonyl)phenothiazin-10-yl]propyl]- (7CI,8CI);1-[3-[2-(Methylsulfonyl)phenothiazin-10-yl]propyl]-4-piperidinecarboxamide;1-[3-[2-(Methylsulfonyl)phenothiazin-10-yl]propyl]isonipecotamide;2-Methylsulfonyl-10-[3-(4-carbamoylpiperidino)propyl]phenothiazine;EXP 999;Metopimazine;RP 9965;Vogalene;? Metopimazine;

Identification

Name4-Piperidinecarboxamide,1-[3-[2-(methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-
CAS14008-44-7
SynonymsIsonipecotamide,1-[3-[2-(methylsulfonyl)phenothiazin-10-yl]propyl]- (7CI,8CI);1-[3-[2-(Methylsulfonyl)phenothiazin-10-yl]propyl]-4-piperidinecarboxamide;1-[3-[2-(Methylsulfonyl)phenothiazin-10-yl]propyl]isonipecotamide;2-Methylsulfonyl-10-[3-(4-carbamoylpiperidino)propyl]phenothiazine;EXP 999;Metopimazine;RP 9965;Vogalene;? Metopimazine;
EINECS(EC#)237-818-4
Molecular FormulaC22H27 N3 O3 S2
Molecular Weight445.64

Chemical Properties

refractive index1.626

Safety Data

Safety

The safety information of Metopimazine (CAS NO.14008-44-7):
Poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. An anti-emetic agent. When heated to decomposition it emits very toxic fumes of SO_x and NO_x.

Toxicity

The toxicity of Metopimazine (CAS NO.14008-44-7):

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	oral	500mg/kg (500mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: TREMOR	Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976.
dog	LD₅₀	oral	500mg/kg (500mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: TREMOR	Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976.
guinea pig	LDLo	oral	250mg/kg (250mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: ATAXIA	Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976.
mouse	LD₅₀	intraperitoneal	78mg/kg (78mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN SENSATION OF SMELL: OLFACTION SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 1, Pg. 97, 1967.
mouse	LD₅₀	intravenous	64mg/kg (64mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN SENSATION OF SMELL: OLFACTION SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 1, Pg. 97, 1967.
mouse	LD₅₀	oral	800mg/kg (800mg/kg)		Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. Vol. 266, Pg. 2365, 1968.
mouse	LD₅₀	subcutaneous	315mg/kg (315mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 32, 1972.
rabbit	LDLo	oral	2gm/kg (2000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: ATAXIA	Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976.
rat	LD₅₀	oral	976mg/kg (976mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat	LD₅₀	subcutaneous	1080mg/kg (1080mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

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4-Piperidinecarboxamide,1-[3-[2-(methylsulfonyl)-10H-phenothiazin-10-yl]propyl]- cas no:14008-44-7

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