1404-93-9|Vancocine hydrochlorideProducts Supply - Chemical intermediates Network

Vancocine hydrochloride cas no:1404-93-9

Synonyms: Lyphocin;Meek;Vancocinehydrochloride;Vancocyn;Vancor;

Identification

NameVancocine hydrochloride
CAS1404-93-9
SynonymsLyphocin;Meek;Vancocinehydrochloride;Vancocyn;Vancor;
EINECS(EC#)215-772-6
Molecular FormulaC₆₆H₇₅Cl₂N₉O₂₄.HCl
Molecular Weight1449.2536

Chemical Properties

Appearanceoff white powder
storage temp2-8°C

Safety Data

Hazard Xi:Irritant
Risk R43
Safety

Poison by intravenous route. Moderately toxic by intraperitoneal routes. Human systemic effects by intravenous route: cardiac arrythmias, blood pressure lowering, and allergic dermatitis. When heated to decomposition it emits toxic fumes of NO_x and HCl.
Hazard Codes?of?Vancocin hydrochloride (CAS NO.1404-93-9):? Irritant Xi
Risk Statements: 43?
R43: May cause sensitization by skin contact
Safety Statements: 36/37-24/25-22-36
S36/37: Wear suitable protective clothing and gloves
S24/25: Avoid contact with skin and eyes
S22: Do not breathe dust
S36: Wear suitable protective clothing
WGK Germany: 2
RTECS: YW4380000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	intravenous	27500ug/kg/10 (27.5mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"	Clinical Pediatrics Vol. 23, Pg. 416, 1984.
guinea pig	LD50	intraperitoneal	737mg/kg (737mg/kg)	KIDNEY, URETER, AND BLADDER: HEMATURIA	Antibiotics Annual. Vol. 4, Pg. 75, 1956/1957.
man	LDLo	intravenous	43mg/kg/2W-I (43mg/kg)	BLOOD: AGRANULOCYTOSIS	American Journal of Medicine. Vol. 81, Pg. 1059, 1986.
man	TDLo	intravenous	1429ug/kg/10- (1.429mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Mayo Clinic Proceedings. Vol. 61, Pg. 721, 1986.
mouse	LD50	intraperitoneal	1734mg/kg (1734mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981.
mouse	LD50	intravenous	489mg/kg (489mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981.
mouse	LD50	oral	> 5gm/kg (5000mg/kg)	?	Antibiotics Annual. Vol. 4, Pg. 75, 1956/1957.
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC	Antibiotics Annual. Vol. 4, Pg. 75, 1956/1957.
rat	LD50	intraperitoneal	2218mg/kg (2218mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981.
rat	LD50	intravenous	319mg/kg (319mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981.
rat	LD50	oral	> 10gm/kg (10000mg/kg)	?	Drugs in Japan Vol. 6, Pg. 597, 1982.
women	TDLo	intraperitoneal	40mg/kg (40mg/kg)	GASTROINTESTINAL: PERITONITIS BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT	American Journal of Kidney Diseases. Vol. 17, Pg. 76, 1991.
women	TDLo	intravenous	20mg/kg (20mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Annals of Internal Medicine. Vol. 101, Pg. 880, 1984.

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Vancocine hydrochloride cas no:1404-93-9

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