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Polymyxin cas no:1406-11-7

Synonyms: Polymixin

Identification
NamePolymyxin
CAS1406-11-7
SynonymsPolymixin
Molecular FormulaC48H82N16O14
Molecular Weight0
Chemical Properties
refractive index1.615
Safety Data

Safety

Poison by intraperitoneal, subcutaneous, and intravenous routes. An additive permitted in food for human consumption.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 25mg/kg (25mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 51, Pg. 935, 1949.
mouse LD50 intraperitoneal 77mg/kg (77mg/kg)   Annals of the New York Academy of Sciences. Vol. 51, Pg. 879, 1949.
mouse LD50 intravenous 18mg/kg (18mg/kg)   Annals of the New York Academy of Sciences. Vol. 51, Pg. 879, 1949.
mouse LD50 subcutaneous 250mg/kg (250mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 51, Pg. 935, 1949.

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