142-47-2|L-Glutamic acid, sodiumsalt (1:1)Products Supply

L-Glutamic acid, sodiumsalt (1:1) cas no:142-47-2

Synonyms: Glutamicacid, monosodium salt, L- (8CI);L-Glutamic acid, monosodium salt (9CI);E 621;Glutacyl;Glutamic acid monosodium salt;L-Glutamic acid sodium salt;Monosodium L-glutamate;Sodium L-glutamate;Sodium hydrogen glutamate;Vetsin;Zest;

Identification

NameL-Glutamic acid, sodiumsalt (1:1)
CAS142-47-2
SynonymsGlutamicacid, monosodium salt, L- (8CI);L-Glutamic acid, monosodium salt (9CI);E 621;Glutacyl;Glutamic acid monosodium salt;L-Glutamic acid sodium salt;Monosodium L-glutamate;Sodium L-glutamate;Sodium hydrogen glutamate;Vetsin;Zest;
EINECS(EC#)205-538-1
Molecular FormulaC₅H₈NNaO₄
Molecular Weight169.11

Chemical Properties

AppearanceWhite crystalline powder.
refractive index25 ° (C=10, 2mol/L HCl)
storage tempKeep tightly closed in a cool place in a tightly closed container.

Safety Data

Risk R20/21/22
Safety

Risk Statements of Monosodium Glutamate (CAS NO.142-47-2): 20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
WGK Germany: 2
RTECS: MA1578000
Moderately toxic by intravenous route. Mildly toxic by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by ingestion and intravenous routes: somnolence, hallucinations and distorted perceptions, headache, dyspnea, nausea or vomiting, dermatitis. The cause of “Chinese restaurant syndrome.” When heated to decomposition it emits toxic fumes of NO_x and Na₂O.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	subcutaneous	8gm/kg (8000mg/kg)		Personal Communication from A.G. Ebert, International Glutamate Technical Committee, 85 Walnu St., Watertown, MA 02172, Nov. 19, 1973Vol. 19NOV1973,
guinea pig	LD50	intraperitoneal	15gm/kg (15000mg/kg)		FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 424, 1974.
human	TDLo	intravenous	714ug/kg (0.714mg/kg)	BEHAVIORAL: HEADACHE	Science. Vol. 163, Pg. 826, 1969.
human	TDLo	oral	43mg/kg (43mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" GASTROINTESTINAL: NAUSEA OR VOMITING	Hygiene and Sanitation Vol. 36(9), Pg. 364, 1971.
man	TDLo	oral	3571ug/kg (3.571mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Lancet. Vol. 1, Pg. 988, 1987.
mouse	LD50	intraperitoneal	3800mg/kg (3800mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 227, Pg. 214, 1955.
mouse	LD50	intravenous	30gm/kg (30000mg/kg)		FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 424, 1974.
mouse	LD50	oral	11400mg/kg (11400mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 227, Pg. 214, 1955.
mouse	LD50	subcutaneous	8200mg/kg (8200mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 433, 1978.
rat	LD50	intraperitoneal	4253mg/kg (4253mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TETANY	Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie. Vol. 300, Pg. 97, 1955.
rat	LD50	intravenous	3300mg/kg (3300mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: ATAXIA AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC	Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 433, 1978.
rat	LD50	oral	16600mg/kg (16600mg/kg)		Farmaco, Edizione Pratica. Vol. 27, Pg. 19, 1972.
rat	LD50	subcutaneous	5580mg/kg (5580mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: ATAXIA	Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 433, 1978.
women	TDLo	oral	50mg/kg (50mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	New England Journal of Medicine. Vol. 305, Pg. 1154, 1981.

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L-Glutamic acid, sodiumsalt (1:1) cas no:142-47-2

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