4-Pyridinecarbothioamide,2-propyl- cas no:14222-60-7

Name4-Pyridinecarbothioamide,2-propyl-
CAS14222-60-7
SynonymsIsonicotinamide,2-propylthio- (6CI,7CI,8CI);1321TH;2-Propyl-4-pyridinecarbothioamide;2-Propylisonicotinylthioamide;2-Propylthioisonicotinamide;9778 R. P.;Ektebin;Protion;Protionamid;Protionamide;Protionizina;RP9778;TH 1321;Tebeform;Trevintix;Tuberex;
EINECS(EC#)238-093-7
Molecular FormulaC₉H₁₂N₂S
Molecular Weight180.27

refractive index1.606

Safety Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NOx and SOx. Used as an antibacterial agent.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

NS0650000

CHEMICAL NAME :

Isonicotinamide, 2-propylthio-

CAS REGISTRY NUMBER :

14222-60-7

BEILSTEIN REFERENCE NO. :

0118164

LAST UPDATED :

199612

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C9-H12-N2-S

MOLECULAR WEIGHT :

180.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1320 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,471,1975

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

760 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,726,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,471,1975

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

660 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,726,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

>1 gm/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,471,1975