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Vinblastine sulfate cas no:143-67-9

Synonyms: Alkaban-AQ;Exal;VLBmonosulfate;Velban;Velbe;Velsar;Vincaleukoblastine derivative;vincaleukoblastine, (2'beta)-;(2'beta)-Vincaleukoblastine;Vincaleukoblastine sulfate (1:1) (salt);Vinblastine 5;Rozevin sulfate;

Identification
NameVinblastine sulfate
CAS143-67-9
SynonymsAlkaban-AQ;Exal;VLBmonosulfate;Velban;Velbe;Velsar;Vincaleukoblastine derivative;vincaleukoblastine, (2'beta)-;(2'beta)-Vincaleukoblastine;Vincaleukoblastine sulfate (1:1) (salt);Vinblastine 5;Rozevin sulfate;
EINECS(EC#)205-606-0
Molecular FormulaC46H58N4O9
Molecular Weight909.06
Chemical Properties
Appearancewhite powder
alpha-21.7 o (C=2, CH3OH 21 oC)
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Safety Data

Hazard T:Toxic
Risk R22;R36/37/38;R41;R61
Safety

Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by intravenous route: blood leukopenia and hair changes. Experimental reproductive effects. Questionable carcinogen. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also?vincaleukoblastine and?sulfates.
Hazard Codes:?HarmfulXn,ToxicT
Risk Statements: 22-37/38-41-61-36/37/38-63-23/24/25
R22:Harmful if swallowed.?
R37/38:Irritating to respiratory system and skin.?
R41:Risk of serious damage to the eyes.?
R61:May cause harm to the unborn child.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R63:Possible risk of harm to the unborn child.?
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36/39-53-45-37/39-36/37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S53:Avoid exposure - obtain special instructions before use.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S37/39:Wear suitable gloves and eye/face protection.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 1544
WGK Germany: 3
RTECS: YY8400000
F: 8-10
HazardClass: 6.1(a)
PackingGroup: II


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 500ug/kg (0.5mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3713-83,
hamster LD50 intraperitoneal 4300ug/kg (4.3mg/kg) ? Cancer Letters Vol. 2, Pg. 267, 1977.
human TDLo intravenous 557ug/kg (0.557mg/kg) BLOOD: LEUKOPENIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Cancer Chemotherapy Reports. Vol. 29, Pg. 111, 1963.
mouse LD50 intraperitoneal 2700ug/kg (2.7mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.
mouse LD50 intravenous 9500ug/kg (9.5mg/kg) ? Cancer Research. Vol. 39, Pg. 3575, 1979.
mouse LD50 oral 423mg/kg (423mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
mouse LD50 subcutaneous 324mg/kg (324mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
rat LD50 intraperitoneal 1mg/kg (1mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3713-83,
rat LD50 intravenous 37mg/kg (37mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
rat LD50 oral 305mg/kg (305mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
rat LD50 subcutaneous 355mg/kg (355mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.

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ZHEJIANG CHEMIALS IM & EXP CORP.
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N-Techem International Co.Ltd.
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Hainan Yueyang Biotech Co.,Ltd.
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Andard-Mount Company Ltd.
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Lianyungang Guiyuan Chempharm Co., Ltd.
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Hainan Xiyuan Chemical Technology Co., Ltd.
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Hwasun Life Science Co., Ltd.
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Taizhou Crene Chempharm Co., Ltd.
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Address: Weiwu Load Economic Developed Zone, Taizhou, Zhejiang 318000,
Hangzhou Kinsey Bio-tech Co.,Ltd
Tel:+86-571-85318381
Address: zhaohui Road
Shanghai Yingxuan Pharmaceutical Science&Technology Co., LTD
Tel:+86-21-60875125
Address: RM431 of BLDG 1,No.2588,Jinhai Road,Pudong New District, Shanghai,CN-201209,China

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