143-67-9|Vinblastine sulfateProducts Supply - Chemical intermediates Network

Vinblastine sulfate cas no:143-67-9

Synonyms: Alkaban-AQ;Exal;VLBmonosulfate;Velban;Velbe;Velsar;Vincaleukoblastine derivative;vincaleukoblastine, (2'beta)-;(2'beta)-Vincaleukoblastine;Vincaleukoblastine sulfate (1:1) (salt);Vinblastine 5;Rozevin sulfate;

Identification

NameVinblastine sulfate
CAS143-67-9
SynonymsAlkaban-AQ;Exal;VLBmonosulfate;Velban;Velbe;Velsar;Vincaleukoblastine derivative;vincaleukoblastine, (2'beta)-;(2'beta)-Vincaleukoblastine;Vincaleukoblastine sulfate (1:1) (salt);Vinblastine 5;Rozevin sulfate;
EINECS(EC#)205-606-0
Molecular FormulaC₄₆H₅₈N₄O₉
Molecular Weight909.06

Chemical Properties

Appearancewhite powder
alpha-21.7 o (C=2, CH3OH 21 oC)
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(a)

Safety Data

Hazard T:Toxic
Risk R22;R36/37/38;R41;R61
Safety

Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by intravenous route: blood leukopenia and hair changes. Experimental reproductive effects. Questionable carcinogen. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x and SO_x. See also?vincaleukoblastine and?sulfates.
Hazard Codes:? Harmful Xn, Toxic T
Risk Statements: 22-37/38-41-61-36/37/38-63-23/24/25
R22:Harmful if swallowed.?
R37/38:Irritating to respiratory system and skin.?
R41:Risk of serious damage to the eyes.?
R61:May cause harm to the unborn child.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R63:Possible risk of harm to the unborn child.?
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36/39-53-45-37/39-36/37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S53:Avoid exposure - obtain special instructions before use.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S37/39:Wear suitable gloves and eye/face protection.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 1544
WGK Germany: 3
RTECS: YY8400000
F: 8-10
HazardClass: 6.1(a)
PackingGroup: II

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	500ug/kg (0.5mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3713-83,
hamster	LD50	intraperitoneal	4300ug/kg (4.3mg/kg)	?	Cancer Letters Vol. 2, Pg. 267, 1977.
human	TDLo	intravenous	557ug/kg (0.557mg/kg)	BLOOD: LEUKOPENIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Cancer Chemotherapy Reports. Vol. 29, Pg. 111, 1963.
mouse	LD50	intraperitoneal	2700ug/kg (2.7mg/kg)	?	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.
mouse	LD50	intravenous	9500ug/kg (9.5mg/kg)	?	Cancer Research. Vol. 39, Pg. 3575, 1979.
mouse	LD50	oral	423mg/kg (423mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
mouse	LD50	subcutaneous	324mg/kg (324mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
rat	LD50	intraperitoneal	1mg/kg (1mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3713-83,
rat	LD50	intravenous	37mg/kg (37mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
rat	LD50	oral	305mg/kg (305mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
rat	LD50	subcutaneous	355mg/kg (355mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.

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Vinblastine sulfate cas no:143-67-9

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