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Benzenesulfonamide,4-amino-N-2-pyridinyl- cas no:144-83-2

Synonyms: Sulfanilamide,N1-2(1H)-pyridylidene- (6CI,7CI);Sulfanilamide, N1-2-pyridyl- (8CI);Sulfanilamide, N4-2-pyridyl- (4CI);2-Sulfanilamidopyridine;2-Sulfapyridine;4-Amino-N-2-pyridinylbenzenesulfonamide;4-[(2-Pyridylamino)sulfonyl]aniline;A-499;Adiplon;Coccoclase;Dagenan;Eubasin;Eubasinum;Haptocil;M and B 693;N-(2-Pyridyl)-4-aminobenzenesulfonamide;N1-2-Pyridylsulfanilamide;NSC 41791;NSC 4753;Piridazol;Pirodazole;Plurazol;Pyriamid;Pyridazol;Relbapiridina;Ronin;Streptosilpyridine;Sulfapyridine;Sulfidin;Sulphapyridine;Thioseptal;Trianon;

Identification
NameBenzenesulfonamide,4-amino-N-2-pyridinyl-
CAS144-83-2
SynonymsSulfanilamide,N1-2(1H)-pyridylidene- (6CI,7CI);Sulfanilamide, N1-2-pyridyl- (8CI);Sulfanilamide, N4-2-pyridyl- (4CI);2-Sulfanilamidopyridine;2-Sulfapyridine;4-Amino-N-2-pyridinylbenzenesulfonamide;4-[(2-Pyridylamino)sulfonyl]aniline;A-499;Adiplon;Coccoclase;Dagenan;Eubasin;Eubasinum;Haptocil;M and B 693;N-(2-Pyridyl)-4-aminobenzenesulfonamide;N1-2-Pyridylsulfanilamide;NSC 41791;NSC 4753;Piridazol;Pirodazole;Plurazol;Pyriamid;Pyridazol;Relbapiridina;Ronin;Streptosilpyridine;Sulfapyridine;Sulfidin;Sulphapyridine;Thioseptal;Trianon;
EINECS(EC#)205-642-7
Molecular FormulaC11H11N3O2S
Molecular Weight249.31
Chemical Properties
Appearancesolid
refractive index1.674
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
HazardclassIRRITANT
Safety Data

Hazard Xi
Risk R36/37/38
Safety

Moderately toxic by intraperitoneal and intravenous routes. Slightly toxic by ingestion. Experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NOx and SOx.
 

Hazard Codes: Xi
Risk Statements:
36:  Irritating to the eyes
37:  Irritating to the respiratory system
38:  Irritating to the skin
Safety Statements:
22:  Do not breathe dust
24:  Avoid contact with skin
25:  Avoid contact with eyes
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing


Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 500mg/kg (500mg/kg) BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Pharmacology and Experimental Therapeutics. Vol. 67, Pg. 454, 1939.
mouse LD50 intraperitoneal 1150mg/kg (1150mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archivum Immunologiae et Therapiae Experimentalis. Vol. 16, Pg. 804, 1968.
mouse LD50 oral 16600mg/kg (16600mg/kg) BEHAVIORAL: TREMOR
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Quarterly Journal of Pharmacy & Pharmacology. Vol. 11, Pg. 217, 1938.
rabbit LDLo oral 20gm/kg (20000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Archives Internationales de Pharmacodynamie et de Therapie. Vol. 62, Pg. 281, 1939.
rat LD50 intravenous 800mg/kg (800mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 367, 1950.
rat LD50 oral 15800mg/kg (15800mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Quarterly Journal of Pharmacy & Pharmacology. Vol. 11, Pg. 217,

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