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Ethanamine,2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (1:1) cas no:147-24-0

Synonyms: Ethanamine,2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (9CI);2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride;Alledryl;Allergina;Amidryl;Bagodryl;Bena;Benadrilhydrochloride;Benison;Benodine;Benzantin;Benzhydrol b-dimethylaminoethyl ether hydrochloride;Denydryl;Dibondrin;Dimedrol;Diphantine;Fenylhist;

Identification
NameEthanamine,2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (1:1)
CAS147-24-0
SynonymsEthanamine,2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (9CI);2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride;Alledryl;Allergina;Amidryl;Bagodryl;Bena;Benadrilhydrochloride;Benison;Benodine;Benzantin;Benzhydrol b-dimethylaminoethyl ether hydrochloride;Denydryl;Dibondrin;Dimedrol;Diphantine;Fenylhist;
EINECS(EC#)205-687-2
Molecular FormulaC17H21NO.HCl
Molecular Weight291.82
Chemical Properties
AppearanceWhite Crystalline powder
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Safety Data

Hazard Xn:Harmful
Risk R22
Safety

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion or skin contact: arrhythmias, ataxia, blood pressure elevation, convulsions, distorted perceptions, eye effects, and hallucinations. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Hazard Codes:?HarmfulXn
Risk Statements: 22?
R22:Harmful if swallowed.
Safety Statements: 36?
S36:Wear suitable protective clothing.
RIDADR: 2811
WGK Germany: 3
RTECS of Benzantin hydrochloride? (CAS NO.147-24-0): KR7000000


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 12500ug/kg (12.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Journal of Pediatrics. Vol. 90, Pg. 1017, 1977.
child TDLo skin 60mg/kg/6H-I (60mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: ATAXIA
Clinical Pediatrics Vol. 25, Pg. 163, 1986.
dog LD50 intravenous 24mg/kg (24mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 227, 1947.
guinea pig LD50 intraperitoneal 75mg/kg (75mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 83, Pg. 120, 1945.
guinea pig LD50 oral 280mg/kg (280mg/kg) ? Journal of Allergy. Vol. 27, Pg. 57, 1956.
guinea pig LD50 subcutaneous 40mg/kg (40mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
hamster LD50 intravenous 18mg/kg (18mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 371, 1949.
mammal (species unspecified) LD50 intraperitoneal 80mg/kg (80mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 328, 1953.
man TDLo oral 10714ug/kg (10.714mg/kg) AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
American Journal of Emergency Medicine. Vol. 4, Pg. 369, 1986.
mouse LD50 intraperitoneal 56mg/kg (56mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 112, Pg. 318, 1954.
mouse LD50 intravenous 20mg/kg (20mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 72, 1955.
mouse LD50 oral 164mg/kg (164mg/kg) ? Drugs in Japan Vol. -, Pg. 550, 1995.
mouse LD50 subcutaneous 99200ug/kg (99.2mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 33, 1958.
pigeon LD50 intramuscular 63mg/kg (63mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 46, Pg. 140, 1957.
rabbit LD50 intravenous 10mg/kg (10mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: EXCITEMENT
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 150, 1945.
rat LD50 intraperitoneal 82mg/kg (82mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 250, 1951.
rat LD50 intravenous 35mg/kg (35mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 2769, 1984.
rat LD50 oral 500mg/kg (500mg/kg) ? Drugs in Japan Vol. 6, Pg. 334, 1982.
rat LD50 subcutaneous 201mg/kg (201mg/kg) ? Yakugaku Zasshi. Journal of Pharmacy. Vol. 81, Pg. 261, 1961.
women TDLo oral 83mg/kg (83mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Critical Care Medicine. Vol. 16, Pg. 1161, 1988.

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