child |
TDLo |
oral |
12500ug/kg (12.5mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) |
Journal of Pediatrics. Vol. 90, Pg. 1017, 1977. |
child |
TDLo |
skin |
60mg/kg/6H-I (60mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: ATAXIA |
Clinical Pediatrics Vol. 25, Pg. 163, 1986. |
dog |
LD50 |
intravenous |
24mg/kg (24mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT |
Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 227, 1947. |
guinea pig |
LD50 |
intraperitoneal |
75mg/kg (75mg/kg) |
? |
Journal of Pharmacology and Experimental Therapeutics. Vol. 83, Pg. 120, 1945. |
guinea pig |
LD50 |
oral |
280mg/kg (280mg/kg) |
? |
Journal of Allergy. Vol. 27, Pg. 57, 1956. |
guinea pig |
LD50 |
subcutaneous |
40mg/kg (40mg/kg) |
BEHAVIORAL: TREMOR
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955. |
hamster |
LD50 |
intravenous |
18mg/kg (18mg/kg) |
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT |
Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 371, 1949. |
mammal (species unspecified) |
LD50 |
intraperitoneal |
80mg/kg (80mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 328, 1953. |
man |
TDLo |
oral |
10714ug/kg (10.714mg/kg) |
AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION |
American Journal of Emergency Medicine. Vol. 4, Pg. 369, 1986. |
mouse |
LD50 |
intraperitoneal |
56mg/kg (56mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT |
Journal of Pharmacology and Experimental Therapeutics. Vol. 112, Pg. 318, 1954. |
mouse |
LD50 |
intravenous |
20mg/kg (20mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: ATAXIA |
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 72, 1955. |
mouse |
LD50 |
oral |
164mg/kg (164mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 550, 1995. |
mouse |
LD50 |
subcutaneous |
99200ug/kg (99.2mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 33, 1958. |
pigeon |
LD50 |
intramuscular |
63mg/kg (63mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING |
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 46, Pg. 140, 1957. |
rabbit |
LD50 |
intravenous |
10mg/kg (10mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: EXCITEMENT |
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 150, 1945. |
rat |
LD50 |
intraperitoneal |
82mg/kg (82mg/kg) |
? |
Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 250, 1951. |
rat |
LD50 |
intravenous |
35mg/kg (35mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 2769, 1984. |
rat |
LD50 |
oral |
500mg/kg (500mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 334, 1982. |
rat |
LD50 |
subcutaneous |
201mg/kg (201mg/kg) |
? |
Yakugaku Zasshi. Journal of Pharmacy. Vol. 81, Pg. 261, 1961. |
women |
TDLo |
oral |
83mg/kg (83mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: COMA
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) |
Critical Care Medicine. Vol. 16, Pg. 1161, 1988. |