Pilocarpine nitrate cas no:148-72-1
Synonyms: (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one; nitric acid;(3S)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one; nitric acid;Pilagan;Pilofrin;Prestwick_282;Pilocarpine mononitrate;2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-, mononitrate;2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S,4R)-, mononitrate;
NamePilocarpine nitrate
CAS148-72-1
Synonyms(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one; nitric acid;(3S)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one; nitric acid;Pilagan;Pilofrin;Prestwick_282;Pilocarpine mononitrate;2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-, mononitrate;2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S,4R)-, mononitrate;
EINECS(EC#)205-723-7
Molecular FormulaC11H16N2O2.HNO3
Molecular Weight271.26978
refractive index81 ° (C=2, H2O)
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard Xn: Harmful;
Risk R22
Safety
Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
.Safety Information of Pilocarpine mononitrate (148-72-1):
Hazard Codes: Xn,T+
Xn: Harmful.gif)
T+: Very Toxic .gif)
Risk Statements: 22-26/28
22: Harmful if swallowed
26/28: Very Toxic by inhalation and if swallowed
Safety Statements: 1-25-45
1: Keep locked up
25: Avoid contact with eyes
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR: 3087
WGK Germany 3
RTECS: TK1455000
F: 3-10
F3: Hygroscopic
F10: Keep under argon.
HazardClass: 6.1(b)
PackingGroup: III
The toxicity of Pilocarpine mononitrate (148-72-1):
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intravenous |
345mg/kg (345mg/kg) |
|
Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 259, 1931. |
| rat |
LD50 |
oral |
911mg/kg (911mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: FLUID INTAKE
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED |
Pharmacologist. Vol. 4, Pg. 176, 1962. |
