4H-Furo[3,2-c]pyran-2(6H)-one,4-hydroxy- cas no:149-29-1

Name4H-Furo[3,2-c]pyran-2(6H)-one,4-hydroxy-
CAS149-29-1
SynonymsPatulin(6CI); 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one; Acetic acid,(2,4-dihydroxy-2H-pyran-3(6H)-ylidene)-, 3,4-lactone; Clairformin; Clavacin;Clavatin; Claviformin; DL-Patulin; Expansin; Expansin (antibiotic); Expansine;Mycoin; Mycoin C; Mycoin C3; NSC 32951; NSC 8120; Patuline; Penicidin; Terinin
EINECS(EC#)205-735-2
Molecular FormulaC7H6 O4
Molecular Weight154.12014

Appearancewhite Crystalline
refractive index1.603
storage temp−20°C

Hazardclass6.1(a)

Hazard T: Toxic;Xn: Harmful;
Risk R25
Safety

Poison by ingestion, subcutaneous, intracerebral, intraperitoneal, intravenous, and possibly other routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic and teratogenic data. An antimicrobial agent. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information of Clavacin (CAS NO.149-29-1):
Hazard Codes: T,Xn,C,F
Risk Statements: 25-38-48/20/22-40-22-34-11 
11:  Highly Flammable
20:  Harmful by inhalation
22:  Harmful if swallowed
25:  Toxic if swallowed
34:  Causes burns
38:  Irritating to the skin
40:  Limited evidence of a carcinogenic effect
48:  Danger of serious damage to health by prolonged exposure
Safety Statements: 45-36/37-36/37/39-26-16
16:  Keep away from sources of ignition - No smoking
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing  
37:  Wear suitable gloves 
39:  Wear eye/face protection 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LD50	unreported	170mg/kg (170mg/kg)		Reviews of Environmental Contamination and Toxicology. Vol. 113, Pg. 47, 1990.
dog	LD50	intravenous	10mg/kg (10mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Food and Cosmetics Toxicology. Vol. 17, Pg. 605, 1979.
hamster	LD50	intraperitoneal	10mg/kg (10mg/kg)		Food and Cosmetics Toxicology. Vol. 18, Pg. 173, 1980.
hamster	LD50	oral	31500ug/kg (31.5mg/kg)		Food and Cosmetics Toxicology. Vol. 18, Pg. 173, 1980.
hamster	LD50	subcutaneous	23mg/kg (23mg/kg)		Food and Cosmetics Toxicology. Vol. 18, Pg. 173, 1980.
mouse	LD50	intracrebral	570ug/kg (0.57mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Toxicology. Vol. 13, Pg. 91, 1979.
mouse	LD50	intraperitoneal	5mg/kg (5mg/kg)		Acta Pharmacologica et Toxicologica. Vol. 2, Pg. 109, 1946.
mouse	LD50	intravenous	5mg/kg (5mg/kg)		"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 439, 1981.
mouse	LD50	oral	17mg/kg (17mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: FATTY LIVER DEGERATION KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Toxicology and Applied Pharmacology. Vol. 45, Pg. 275, 1978.
mouse	LD50	subcutaneous	10mg/kg (10mg/kg)	BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Food and Cosmetics Toxicology. Vol. 18, Pg. 181, 1980.
mouse	LDLo	unreported	8mg/kg (8mg/kg)		British Journal of Cancer. Vol. 15, Pg. 85, 1961.
rabbit	LDLo	intravenous	12mg/kg (12mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: PLEURAL EFFUSION	Lancet. Vol. 245, Pg. 631, 1943.
rat	LD50	intraperitoneal	4590ug/kg (4.59mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: OTHER CHANGES	Annales Recherches Veterinaires. Vol. 8, Pg. 41, 1977.
rat	LD50	intravenous	8570ug/kg (8.57mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: OTHER CHANGES	Annales Recherches Veterinaires. Vol. 8, Pg. 41, 1977.
rat	LD50	oral	27790ug/kg (27.79mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: OTHER CHANGES	Annales Recherches Veterinaires. Vol. 8, Pg. 41, 1977.
rat	LD50	subcutaneous	11mg/kg (11mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Food and Chemical Toxicology. Vol. 20, Pg. 289, 1982.