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Urea,N-(4-ethoxyphenyl)- cas no:150-69-6

Synonyms: Urea,(4-ethoxyphenyl)- (9CI); Urea, (p-ethoxyphenyl)- (8CI); (4-Ethoxyphenyl)urea;(p-Ethoxyphenyl)urea; 1-(4-Ethoxyphenyl)urea; 4-Ureidophenetole; Dulcin; Dulcin(sweetener); Dulcine; N-(4-Ethoxyphenyl)urea; NSC 1839; Phenetolcarbamide;Sucrol; Valzin; p-Phenetolcarbamide; p-Phenetylurea

Identification
NameUrea,N-(4-ethoxyphenyl)-
CAS150-69-6
SynonymsUrea,(4-ethoxyphenyl)- (9CI); Urea, (p-ethoxyphenyl)- (8CI); (4-Ethoxyphenyl)urea;(p-Ethoxyphenyl)urea; 1-(4-Ethoxyphenyl)urea; 4-Ureidophenetole; Dulcin; Dulcin(sweetener); Dulcine; N-(4-Ethoxyphenyl)urea; NSC 1839; Phenetolcarbamide;Sucrol; Valzin; p-Phenetolcarbamide; p-Phenetylurea
EINECS(EC#)150-69-6 [RN]
Molecular FormulaC9H12 N2 O2
Molecular Weight180.23
Chemical Properties
refractive index1.59
storage temp0-6°C
Safety Data

Hazard Xi: Irritant;
Safety

Human poison by ingestion. Moderately toxic experimentally by ingestion. Human systemic effects by ingestion: somnolence, hallucinations, distorted perceptions, and changes in motor activity. In adults 20 to 40 g produces dizziness, nausea, methemoglobinemia, cyanosis, and hypotension. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.
 

Hazard Note: Irritant
Hazard Codes: Xi


Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child LDLo oral 400mg/kg (400mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: MUSCLE WEAKNESS
GASTROINTESTINAL: NAUSEA OR VOMITING
Medizinische Klinik. Vol. 43, Pg. 105, 1948.
dog LDLo oral 1gm/kg (1000mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1345, 1935.
mouse LD50 oral 700mg/kg (700mg/kg)   FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 100, 1967.
mouse LDLo intraperitoneal 135mg/kg (135mg/kg) BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 188, 1935.
rabbit LD50 oral 4gm/kg (4000mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52, Pg. 215, 1956.
rat LD50 oral 3200mg/kg (3200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 150, 1958.
women TDLo oral 600mg/kg (600mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Medizinische Klinik. Vol. 43, Pg. 105, 1948.

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Nanjing Biorgchem Co., Ltd.
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Kanto Chemical Co., Inc.
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R S A Corp
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R.S.A Corp
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Hangzhou J&H Chemical Co., Ltd
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Finetech Industry limited.
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Boc Sciences
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Nanjing Chemlin Chemical Co., Ltd.
Tel:86-25-83697070
Address: Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China
Wuhan H.X.K Fine Chemicals Co.,LTD
Tel:86-27-59721024
Address: No. 139, hanyang Road, hubei city, Hubei Prov. China 434000

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