Urea,N-(4-ethoxyphenyl)- cas no:150-69-6
Synonyms: Urea,(4-ethoxyphenyl)- (9CI); Urea, (p-ethoxyphenyl)- (8CI); (4-Ethoxyphenyl)urea;(p-Ethoxyphenyl)urea; 1-(4-Ethoxyphenyl)urea; 4-Ureidophenetole; Dulcin; Dulcin(sweetener); Dulcine; N-(4-Ethoxyphenyl)urea; NSC 1839; Phenetolcarbamide;Sucrol; Valzin; p-Phenetolcarbamide; p-Phenetylurea
NameUrea,N-(4-ethoxyphenyl)-
CAS150-69-6
SynonymsUrea,(4-ethoxyphenyl)- (9CI); Urea, (p-ethoxyphenyl)- (8CI); (4-Ethoxyphenyl)urea;(p-Ethoxyphenyl)urea; 1-(4-Ethoxyphenyl)urea; 4-Ureidophenetole; Dulcin; Dulcin(sweetener); Dulcine; N-(4-Ethoxyphenyl)urea; NSC 1839; Phenetolcarbamide;Sucrol; Valzin; p-Phenetolcarbamide; p-Phenetylurea
EINECS(EC#)150-69-6 [RN]
Molecular FormulaC9H12 N2 O2
Molecular Weight180.23
refractive index1.59
storage temp0-6°C
Hazard Xi: Irritant;
Safety
Human poison by ingestion. Moderately toxic experimentally by ingestion. Human systemic effects by ingestion: somnolence, hallucinations, distorted perceptions, and changes in motor activity. In adults 20 to 40 g produces dizziness, nausea, methemoglobinemia, cyanosis, and hypotension. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.
Hazard Note: Irritant
Hazard Codes: Xi.gif)
Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
child |
LDLo |
oral |
400mg/kg (400mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: MUSCLE WEAKNESS
GASTROINTESTINAL: NAUSEA OR VOMITING |
Medizinische Klinik. Vol. 43, Pg. 105, 1948. |
dog |
LDLo |
oral |
1gm/kg (1000mg/kg) |
|
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1345, 1935. |
mouse |
LD50 |
oral |
700mg/kg (700mg/kg) |
|
FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 100, 1967. |
mouse |
LDLo |
intraperitoneal |
135mg/kg (135mg/kg) |
BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 188, 1935. |
rabbit |
LD50 |
oral |
4gm/kg (4000mg/kg) |
|
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52, Pg. 215, 1956. |
rat |
LD50 |
oral |
3200mg/kg (3200mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 150, 1958. |
women |
TDLo |
oral |
600mg/kg (600mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Medizinische Klinik. Vol. 43, Pg. 105, 1948. |