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Betamethasone 21-phosphate disodium cas no:151-73-5

Synonyms: Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11b,16b)- (9CI);Bentelan;Betamethasone 21-phosphate disodium salt;Betnesol;Celestan solubile;Disodium betamethasone 21-phosphate;Durabetason;NSC 90616;Steronema;Vista-Methasone;

Identification
NameBetamethasone 21-phosphate disodium
CAS151-73-5
SynonymsPregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11b,16b)- (9CI);Bentelan;Betamethasone 21-phosphate disodium salt;Betnesol;Celestan solubile;Disodium betamethasone 21-phosphate;Durabetason;NSC 90616;Steronema;Vista-Methasone;
EINECS(EC#)205-797-0
Molecular FormulaC22H28FNa2O8P
Molecular Weight516.41
Chemical Properties
Appearancewhite powder
Safety Data

Hazard Xn:Harmful
Risk R22
Safety

The safety information of Betamethasone disodium phosphate (CAS NO.151-73-5) is as follows:
Hazard Codes: Xn
Risk Statements: 22
22: Harmful if swallowed
Safety Statements: 36
36: Wear suitable protective clothing
WGK Germany: 3
RTECS: TU4056500
Moderately toxic by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F, POx and Na2O.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1166mg/kg (1166mg/kg)   Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
mouse LD50 intravenous 1304mg/kg (1304mg/kg)   Drugs in Japan Vol. -, Pg. 1075, 1990.
mouse LD50 oral 1607mg/kg (1607mg/kg)   Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
mouse LD50 subcutaneous 1363mg/kg (1363mg/kg)   Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
rat LD50 intramuscular 1291mg/kg (1291mg/kg)   Drugs in Japan Vol. -, Pg. 1075, 1990.
rat LD50 intraperitoneal 1179mg/kg (1179mg/kg)   Drugs in Japan Vol. -, Pg. 1075, 1990.
rat LD50 intravenous 1276mg/kg (1276mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
rat LD50 oral 1877mg/kg (1877mg/kg)   Drugs in Japan Vol. -, Pg. 1075, 1990.
rat LD50 subcutaneous 1265mg/kg (1265mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 52, Pg. 105, 1996.

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