(+/-)-Verapamil hydrochloride cas no:152-11-4
Synonyms: Benzeneacetonitrile,a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-,monohydrochloride (9CI);Valeronitrile, 5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-,monohydrochloride (8CI);Akilen;Anpec;Apoacor;Arapamyl;Berkatens;Calan SR;Calaptin 240SR;Calaptin 80;Cardiabeltin;Civicor Retard;Cordilox;Dignover;Dilacoran HTA;Finoptin;
Name(+/-)-Verapamil hydrochloride
CAS152-11-4
SynonymsBenzeneacetonitrile,a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-,monohydrochloride (9CI);Valeronitrile, 5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-,monohydrochloride (8CI);Akilen;Anpec;Apoacor;Arapamyl;Berkatens;Calan SR;Calaptin 240SR;Calaptin 80;Cardiabeltin;Civicor Retard;Cordilox;Dignover;Dilacoran HTA;Finoptin;
EINECS(EC#)205-800-5
Molecular FormulaC27H38N2O4.HCl
Molecular Weight491.06256
Appearancewhite to off-white powder.
storage tempRefrigerator (+4°C)
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard T: Toxic;
Risk R23/24/25
Safety
Safety Information of Verapamil hydrochloride (CAS NO.152-11-4):
Hazard Codes:T 
Risk Statements:25-23/24/25
Safety Statements:45-36/37/39-36/37
RIDADR:UN 2811 6.1/PG 3
WGK Germany:3
RTECS:YV8320000
F:8-10
HazardClass:6.1(b)
PackingGroup:III
Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects; arrhythmias, cardiomyopathy, coma, cyanosis, dyspnea, fall in blood pressure, mydriasis, pulse rate decrease. Human reproductive effects: impotence. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and HCl.
| 1. |
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cyt-hmn:lyms 30 μmol/L
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MUREAV ?? Mutation Research. 244 (1990),135. |
| 2. |
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orl-man TDLo:26?mg/kg:CVS,PUL
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HUTODJ ?? Human Toxicology. 4 (1985),327. |
| 3. |
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orl-man TDLo:143?μg/kg/4H-C:CVS
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ICMED9 ?? Intensive Care Medicine. 8 (1982),55. |
| 4. |
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ivn-man LDLo:256?μg/kg/1H-I:CVS
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AEMED3 ?? Annals of Emergency Medicine. 14 (1985),159. |
| 5. |
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ivn-man TDLo:71?μg/kg/5M-C
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SMJOAV ?? Southern Medical Journal. 75 (1982),1429. |
| 6. |
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orl-wmn TDLo:135?mg/kg:EYE,PUL
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AJCDAG ?? American Journal of Cardiology. 58 (1986),1142. |
| 7. |
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ivn-wmn TDLo:200?μg/kg/15S-C:CVS,PUL
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NYSJAM ?? New York State Journal of Medicine. 83 (1983),1181. |
| 8. |
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orl-inf TDLo:80?mg/kg
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PEDIAU ?? Pediatrics. 73 (1984),543. |
| 9. |
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ivn-inf TDLo:1026?μg/kg:CVS
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ADCHAK ?? Archives of Disease in Childhood. 58 (1983),465. |
| 10. |
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orl-rat LD50:108?mg/kg
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NIIRDN ?? “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),766. |
