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diclofenac sodium cas no:15307-79-6

Synonyms: Diclofenac sodium salt; 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid sodium salt; sodium [2-[(2,6-dichlorophenyl)amino]phenyl]acetate; 2[(2,6-dichlorophenyl)amino]-benzeneacetic aci monosodium

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Identification
Namediclofenac sodium
CAS15307-79-6
SynonymsDiclofenac sodium salt; 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid sodium salt; sodium [2-[(2,6-dichlorophenyl)amino]phenyl]acetate; 2[(2,6-dichlorophenyl)amino]-benzeneacetic aci monosodium
EINECS(EC#)239-346-4
Molecular FormulaC14H10Cl2NNaO2
Molecular Weight318.13
Chemical Properties
Appearancewhite or off-white powder
storage tempKeep tightly closed.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard T:Toxic
Risk R25
Safety

The Hazard Codes of Diclofenac sodium (CAS NO.15307-79-6): T,?? Xi
Risk Statements:
25:? Toxic if swallowed?
36/37/38:? Irritating to eyes, respiratory system and skin?
Safety Statements:
22:? Do not breathe dust?
26:? In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
36:? Wear suitable protective clothing?
45:? In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)?
36/37:? Wear suitable protective clothing and gloves


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 42mg/kg (42mg/kg) ? Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
dog LD50 oral 59mg/kg (59mg/kg) ? Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
mouse LD50 intraperitoneal 74mg/kg (74mg/kg) ? Pharmaceutical Chemistry Journal Vol. 27, Pg. 343, 1993.
mouse LD50 intravenous 116mg/kg (116mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
mouse LD50 oral 95mg/kg (95mg/kg) ? Pharmaceutical Chemistry Journal Vol. 23, Pg. 579, 1989.
mouse LD50 subcutaneous 390mg/kg (390mg/kg) ? Drugs in Japan Vol. 6, Pg. 311, 1982.
mouse LD50 unreported 380mg/kg (380mg/kg) ? Pharmaceutical Chemistry Journal Vol. 21, Pg. 275, 1987.
rabbit LD50 intravenous > 100mg/kg (100mg/kg) ? Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
rabbit LD50 oral 157mg/kg (157mg/kg) ? Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
rat LD50 intraperitoneal 25mg/kg (25mg/kg) ? Drugs in Japan Vol. 6, Pg. 311, 1982.
rat LD50 intravenous 117mg/kg (117mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat LD50 oral 53mg/kg (53mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 28, Pg. 99, 1981.
rat LD50 rectal 85400ug/kg (85.4mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 2259, 1986.
rat LD50 subcutaneous 83mg/kg (83mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
women TDLo intramuscular 9mg/kg/1W-I (9mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
BLOOD: NORMOCYTIC ANEMIA		 American Journal of Hematology. Vol. 58, Pg. 142, 1998.
women TDLo intramuscular 15mg/kg/5D-I (15mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
GASTROINTESTINAL: OTHER CHANGES		 Lancet. Vol. 340, Pg. 126, 1992.
women TDLo oral 30mg/kg/10D-I (30mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Postgraduate Medical Journal. Vol. 69, Pg. 486, 1993.
women TDLo oral 112mg/kg/8W-I (112mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
GASTROINTESTINAL: OTHER CHANGES		 Archives of Internal Medicine. Vol. 152, Pg. 625, 1992.
women TDLo oral 180mg/kg/13W- (180mg/kg) BEHAVIORAL: ANOREXIA (HUMAN
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
KIDNEY, URETER, AND BLADDER: PROTEINURIS		 British Medical Journal. Vol. 295, Pg. 182, 1987.
women TDLo oral 183mg/kg/26W- (183mg/kg) LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"		 British Journal of Clinical Practice. Vol. 43, Pg. 125, 1989.
women TDLo oral 270mg/kg/90D- (270mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE
GASTROINTESTINAL: OTHER CHANGES
BLOOD: CHANGES IN ERYTHROCYTE (RBC) COUNT		 Archives of Internal Medicine. Vol. 152, Pg. 625, 1992.
women TDLo oral 300mg/kg/17W- (300mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED Clinical Rheumatology. Vol. 11, Pg. 120, 1992.
women TDLo oral 2190mg/kg/2Y- (2190mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" American Journal of Gastroenterology. Vol. 90, Pg. 1871, 1995.
women TDLo unreported 364mg/kg/26W- (364mg/kg) KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
KIDNEY, URETER, AND BLADDER: PROTEINURIS		 Wiener Klinische Wochenschrift. Vol. 111, Pg. 523, 1999.
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