15307-79-6|diclofenac sodiumProducts Supply - Chemical intermediates Network

diclofenac sodium cas no:15307-79-6

Synonyms: Diclofenac sodium salt; 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid sodium salt; sodium [2-[(2,6-dichlorophenyl)amino]phenyl]acetate; 2[(2,6-dichlorophenyl)amino]-benzeneacetic aci monosodium

Identification

Namediclofenac sodium
CAS15307-79-6
SynonymsDiclofenac sodium salt; 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid sodium salt; sodium [2-[(2,6-dichlorophenyl)amino]phenyl]acetate; 2[(2,6-dichlorophenyl)amino]-benzeneacetic aci monosodium
EINECS(EC#)239-346-4
Molecular FormulaC14H10Cl2NNaO2
Molecular Weight318.13

Chemical Properties

Appearancewhite or off-white powder
storage tempKeep tightly closed.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard T:Toxic
Risk R25
Safety

The Hazard Codes of Diclofenac sodium (CAS NO.15307-79-6): T,?? Xi
Risk Statements:
25:? Toxic if swallowed?
36/37/38:? Irritating to eyes, respiratory system and skin?
Safety Statements:
22:? Do not breathe dust?
26:? In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
36:? Wear suitable protective clothing?
45:? In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)?
36/37:? Wear suitable protective clothing and gloves

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	42mg/kg (42mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
dog	LD50	oral	59mg/kg (59mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
mouse	LD50	intraperitoneal	74mg/kg (74mg/kg)	?	Pharmaceutical Chemistry Journal Vol. 27, Pg. 343, 1993.
mouse	LD50	intravenous	116mg/kg (116mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
mouse	LD50	oral	95mg/kg (95mg/kg)	?	Pharmaceutical Chemistry Journal Vol. 23, Pg. 579, 1989.
mouse	LD50	subcutaneous	390mg/kg (390mg/kg)	?	Drugs in Japan Vol. 6, Pg. 311, 1982.
mouse	LD50	unreported	380mg/kg (380mg/kg)	?	Pharmaceutical Chemistry Journal Vol. 21, Pg. 275, 1987.
rabbit	LD50	intravenous	> 100mg/kg (100mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
rabbit	LD50	oral	157mg/kg (157mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
rat	LD50	intraperitoneal	25mg/kg (25mg/kg)	?	Drugs in Japan Vol. 6, Pg. 311, 1982.
rat	LD50	intravenous	117mg/kg (117mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat	LD50	oral	53mg/kg (53mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 28, Pg. 99, 1981.
rat	LD50	rectal	85400ug/kg (85.4mg/kg)	?	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 2259, 1986.
rat	LD50	subcutaneous	83mg/kg (83mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
women	TDLo	intramuscular	9mg/kg/1W-I (9mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: NORMOCYTIC ANEMIA	American Journal of Hematology. Vol. 58, Pg. 142, 1998.
women	TDLo	intramuscular	15mg/kg/5D-I (15mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" GASTROINTESTINAL: OTHER CHANGES	Lancet. Vol. 340, Pg. 126, 1992.
women	TDLo	oral	30mg/kg/10D-I (30mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Postgraduate Medical Journal. Vol. 69, Pg. 486, 1993.
women	TDLo	oral	112mg/kg/8W-I (112mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" GASTROINTESTINAL: OTHER CHANGES	Archives of Internal Medicine. Vol. 152, Pg. 625, 1992.
women	TDLo	oral	180mg/kg/13W- (180mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" KIDNEY, URETER, AND BLADDER: PROTEINURIS	British Medical Journal. Vol. 295, Pg. 182, 1987.
women	TDLo	oral	183mg/kg/26W- (183mg/kg)	LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)" LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"	British Journal of Clinical Practice. Vol. 43, Pg. 125, 1989.
women	TDLo	oral	270mg/kg/90D- (270mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE GASTROINTESTINAL: OTHER CHANGES BLOOD: CHANGES IN ERYTHROCYTE (RBC) COUNT	Archives of Internal Medicine. Vol. 152, Pg. 625, 1992.
women	TDLo	oral	300mg/kg/17W- (300mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED	Clinical Rheumatology. Vol. 11, Pg. 120, 1992.
women	TDLo	oral	2190mg/kg/2Y- (2190mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	American Journal of Gastroenterology. Vol. 90, Pg. 1871, 1995.
women	TDLo	unreported	364mg/kg/26W- (364mg/kg)	KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED KIDNEY, URETER, AND BLADDER: PROTEINURIS	Wiener Klinische Wochenschrift. Vol. 111, Pg. 523, 1999. ?

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diclofenac sodium cas no:15307-79-6

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