1H-Azepinium,1-(4-amino-4-oxo-3,3-diphenylbutyl)hexahydro-1-methyl-, iodide (1:1) cas no:15351-05-0

Name1H-Azepinium,1-(4-amino-4-oxo-3,3-diphenylbutyl)hexahydro-1-methyl-, iodide (1:1)
CAS15351-05-0
Synonyms1-(3-Carbamoyl-3,3-diphenylpropyl)hexahydro-1-methylazepiniumiodide (6CI); 1H-Azepinium,1-(3-carbamoyl-3,3-diphenylpropyl)hexahydro-1-methyl-, iodide (8CI);1H-Azepinium, 1-(4-amino-4-oxo-3,3-diphenylbutyl)hexahydro-1-methyl-, iodide(9CI); 1-(3-Carbamoyl-3,3-diphenylpropyl) perhydro-1-methylazepinium iodide;2,2-Diphenyl-4-hexamethyleniminobutyramide methiodide; Buzepide methiodide;Buzepide metiodide; Difexamide methiodide; Diphexamide methiodide; FI 6146;Metazepium iodide; R 661; Spactin
EINECS(EC#)239-383-6
Molecular FormulaC23H31 N2 O . I
Molecular Weight478.46

Safety

A poison by intraperitoneal, intravenous, intramuscular, and subcutaneous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of I⁻ and NO_x. See also IODIDES.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intramuscular	201mg/kg (201mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
mouse	LD50	intraperitoneal	94mg/kg (94mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
mouse	LD50	intravenous	14mg/kg (14mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
mouse	LD50	oral	820mg/kg (820mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS	Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
mouse	LD50	subcutaneous	229mg/kg (229mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
rat	LD50	intramuscular	800mg/kg (800mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
rat	LD50	intraperitoneal	145mg/kg (145mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
rat	LD50	intravenous	29300ug/kg (29.3mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
rat	LD50	oral	2800mg/kg (2800mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS	Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
rat	LD50	subcutaneous	1210mg/kg (1210mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.