154-69-8|1,2-Ethanediamine,N1,N1-dimethyl-N2-(phenylmethyl)-N2-2-pyridinyl-, hydrochloride (1:1)Products Supply

1,2-Ethanediamine,N1,N1-dimethyl-N2-(phenylmethyl)-N2-2-pyridinyl-, hydrochloride (1:1) cas no:154-69-8

Synonyms: 1,2-Ethanediamine,N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, monohydrochloride (9CI);Pyridine, 2-[benzyl[2-(dimethylamino)ethyl]amino]-, monohydrochloride (8CI);2-[Benzyl[2-(dimethylamino)ethyl]amino]pyridine hydrochloride;Dehistin monohydrochloride;N,N-Dimethyl-N'-(2-pyridyl)-N'-benzylethylenediamine hydrochloride;NIH 10186;PBZ;Piristin;Pyribenzamine monohydrochloride;Pyrinamine;ReCovr;Stanzamine;Tripelennamine hydrochloride;Tripelennamine monohydrochloride;Vetibenzamine;Vetobenzamina;

Identification

Name1,2-Ethanediamine,N1,N1-dimethyl-N2-(phenylmethyl)-N2-2-pyridinyl-, hydrochloride (1:1)
CAS154-69-8
Synonyms1,2-Ethanediamine,N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, monohydrochloride (9CI);Pyridine, 2-[benzyl[2-(dimethylamino)ethyl]amino]-, monohydrochloride (8CI);2-[Benzyl[2-(dimethylamino)ethyl]amino]pyridine hydrochloride;Dehistin monohydrochloride;N,N-Dimethyl-N'-(2-pyridyl)-N'-benzylethylenediamine hydrochloride;NIH 10186;PBZ;Piristin;Pyribenzamine monohydrochloride;Pyrinamine;ReCovr;Stanzamine;Tripelennamine hydrochloride;Tripelennamine monohydrochloride;Vetibenzamine;Vetobenzamina;
EINECS(EC#)205-833-5
Molecular FormulaC₁₆H₂₂ClN₃
Molecular Weight291.86

Chemical Properties

AppearanceWhite solid

Safety Data

Hazard Xn: Harmful;
Risk R22
Safety

A human poison by an unspecified route. An experimental poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x and HCl.
Hazard Codes Harmful Xn
Risk Statements 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany 3
RTECS US3150000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	20mg/kg (20mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1916, 1969.
dog	LDLo	oral	23mg/kg (23mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Bulletin of the Johns Hopkins Hospital. Vol. 81, Pg. 55, 1947.
guinea pig	LD50	oral	150mg/kg (150mg/kg)		Journal of Allergy. Vol. 27, Pg. 57, 1956.
guinea pig	LD50	subcutaneous	30mg/kg (30mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
hamster	LD50	intravenous	13mg/kg (13mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 371, 1949.
man	LDLo	unreported	15mg/kg (15mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LD50	intraperitoneal	47mg/kg (47mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Clinical Toxicology. Vol. 16, Pg. 17, 1980.
mouse	LD50	intravenous	9mg/kg (9mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Pharmacology and Experimental Therapeutics. Vol. 92, Pg. 249, 1948.
mouse	LD50	oral	97mg/kg (97mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 488, 1950.
mouse	LD50	subcutaneous	41mg/kg (41mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
rabbit	LD50	intravenous	9mg/kg (9mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 749, 1946.
rabbit	LD50	subcutaneous	33mg/kg (33mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 749, 1946.
rat	LD50	intravenous	12mg/kg (12mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 749, 1946.
rat	LD50	oral	469mg/kg (469mg/kg)		Journal of Pharmaceutical Sciences. Vol. 69, Pg. 1198, 1980.
rat	LD50	subcutaneous	75mg/kg (75mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 78, Pg. 708, 1951.

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Hangzhou J&H Chemical Co., Ltd: Tel:86-571-87396430; Address: No.200 Zhenhua Rd.Xihu Industrial Park, Hangzhou 310030, China

1,2-Ethanediamine,N1,N1-dimethyl-N2-(phenylmethyl)-N2-2-pyridinyl-, hydrochloride (1:1) cas no:154-69-8

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