154-93-8|CarmustinProducts Supply - Chemical intermediates Network

Carmustin cas no:154-93-8

Synonyms: Urea,1,3-bis(2-chloroethyl)-1-nitroso- (8CI);1,3-Bis(b-chloroethyl)-1-nitrosourea;BCNU;Becenun;BiCNU;DTI 015;FDA 0345;Gliadel;Gliadel Wafer;N,N'-Bis(2-chloroethyl)-N-nitrosourea;NSC 409962;Nitrumon;SK 27702;SRI 1720;

Identification

NameCarmustin
CAS154-93-8
SynonymsUrea,1,3-bis(2-chloroethyl)-1-nitroso- (8CI);1,3-Bis(b-chloroethyl)-1-nitrosourea;BCNU;Becenun;BiCNU;DTI 015;FDA 0345;Gliadel;Gliadel Wafer;N,N'-Bis(2-chloroethyl)-N-nitrosourea;NSC 409962;Nitrumon;SK 27702;SRI 1720;
EINECS(EC#)205-838-2
Molecular FormulaC₅H₉Cl₂N₃O₂
Molecular Weight214.05

Chemical Properties

AppearanceOrange-yellow solid.
refractive index1.548
storage temp?20°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(a)

Safety Data

Hazard T+:Verytoxic;
Risk R45;R46;R60;R61;R28
Safety

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. A human poison by parenteral route. An experimental poison by ingestion, intravenous, intraperitoneal, parenteral, and subcutaneous routes. Human systemic effects by parenteral, intravenous, and possibly other routes: nausea or vomiting, reduced white blood cell and blood platelet counts, bone marrow damage, and potentially fatal respiratory system effects including lung fibrosis, dyspnea, and cyanosis. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl^? and NO_x. See also N-NITROSO COMPOUNDS.
Safety information of Carmustin (CAS NO.154-93-8):
Hazard Codes: T+
Risk Statements: 45-46-60-61-28
R45:May cause cancer ;
R46:May cause heritable genetic damage ;
R60:May impair fertility ;
R61:May cause harm to the unborn child ;
R28:Very Toxic if swallowed ;
Safety Statements: 53-22-36/37/39-45
S53:Avoid exposure - obtain special instruction before use ;
S22:Do not breathe dust ;
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection ;
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) ;
RIDADR: 3249
WGK Germany: 3
RTECS: YS2625000
HazardClass: 6.1(a)
PackingGroup: II

Toxicity

1.	???	mmo-sat 33?μg/plate	???	TCMUD8 ?? Teratogenesis, Carcinogenesis, and Mutagenesis. 5 (1985),319.
2.	???	sce-hmn:lym 25 μmol/L	???	CNREA8 ?? Cancer Research. 45 (1985),4798.
3.	???	ivn-cld LDLo:78?mg/kg/52W I	???	CANCAR ?? Cancer. 42 (1978),74.
4.	???	ivn-hmn TDLo:125?mg/kg:BLD,GIT	???	ACRSAJ ?? Advances in Cancer Research. 16 (1972),273.
5.	???	ivn-hmn TDLo:6?mg/kg:BLD,GIT	???	CTRRDO ?? Cancer Treatment Reports. 60 (1976),709.
6.	???	par-wmn LDLo:1566?mg/kg:PUL	???	JAMAAP ?? JAMA, Journal of the American Medical Association. 244 (1980),687.
7.	???	orl-rat LD50:20?mg/kg	???	JPETAB ?? Journal of Pharmacology and Experimental Therapeutics. 166 (1969),104.
8.	???	ipr-rat LD50:17,420?μg/kg	???	NCISP* ?? National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 .
9.	???	scu-rat LD50:83,200?μg/kg	???	IYKEDH ?? Iyakuhin Kenkyu. Study of Medical Supplies. 9 (1978),766.
10.	???	ivn-rat LD50:13,800?μg/kg	???	ONCOBS ?? Oncology. 37 (1980),177.

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Carmustin cas no:154-93-8

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