child |
TDLo |
unreported |
19200ug/kg/12 (19.2mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR |
Journal of Pediatrics. Vol. 103, Pg. 1006, 1983. |
dog |
LDLo |
intravenous |
2500ug/kg (2.5mg/kg) |
GASTROINTESTINAL: OTHER CHANGES
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN |
Toxicology and Applied Pharmacology. Vol. 25, Pg. 230, 1973. |
frog |
LD50 |
parenteral |
17mg/kg (17mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
Journal of Comparative Pathology. Vol. 103, Pg. 387, 1990. |
guinea pig |
LD50 |
intraperitoneal |
9700ug/kg (9.7mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR |
Toxicology and Applied Pharmacology. Vol. 33, Pg. 320, 1975. |
human |
TDLo |
intradermal |
40ng/kg (0.00004mg/kg) |
SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE
SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE |
Cancer Research. Vol. 35, Pg. 2766, 1975. |
human |
TDLo |
intravenous |
500ug/kg/13D- (0.5mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED
BLOOD: OTHER CHANGES |
Cancer Treatment Reports. Vol. 62, Pg. 693, 1978. |
human |
TDLo |
intravenous |
1500ug/kg/6D- (1.5mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR
KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE |
Cancer Chemotherapy Reports, Part 1. Vol. 57, Pg. 191, 1973. |
human |
TDLo |
intravenous |
2500ug/kg (2.5mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
GASTROINTESTINAL: NAUSEA OR VOMITING
KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED |
Cancer Chemotherapy Reports, Part 1. Vol. 59, Pg. 647, 1975. |
human |
TDLo |
intravenous |
72mg/kg/25D-I (72mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING |
Cancer Treatment Reports. Vol. 62, Pg. 1591, 1978. |
mammal (species unspecified) |
LDLo |
intravenous |
8mg/kg (8mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 28(4), Pg. 285, 2000. |
man |
TDLo |
intravenous |
2140ug/kg/5D- (2.14mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
Japanese Journal of Medicine. Vol. 23, Pg. 283, 1984. |
man |
TDLo |
parenteral |
2140ug/kg/5D- (2.14mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
Nippon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine. Vol. 72, Pg. 1426, 1983. |
monkey |
LDLo |
intravenous |
250ug/kg (0.25mg/kg) |
? |
Cancer Vol. 33, Pg. 1219, 1974. |
mouse |
LD50 |
intramuscular |
17900ug/kg (17.9mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BLOOD: NORMOCYTIC ANEMIA |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 723, 1982. |
mouse |
LD50 |
intraperitoneal |
6600ug/kg (6.6mg/kg) |
? |
Journal of Medicinal Chemistry. Vol. 34, Pg. 414, 1991. |
mouse |
LD50 |
intravenous |
11mg/kg (11mg/kg) |
? |
Archives of Toxicology, Supplement. Vol. 7, Pg. 90, 1984. |
mouse |
LD50 |
oral |
32700ug/kg (32.7mg/kg) |
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED |
Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 5669, 1981. |
mouse |
LD50 |
parenteral |
22mg/kg (22mg/kg) |
? |
International Journal of Radiation Oncology, Biology, Physics. Vol. 5, Pg. 1417, 1979. |
mouse |
LD50 |
subcutaneous |
13mg/kg (13mg/kg) |
? |
Journal de Pharmacie de Belgique. Vol. 41, Pg. 286, 1986. |
mouse |
LD50 |
unreported |
10900ug/kg (10.9mg/kg) |
? |
Gan to Kagaku Ryoho. Cancer and Chemotherapy. Vol. 13, Pg. 280, 1986. |
rat |
LD |
unreported |
> 5mg/kg (5mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
Journal of Toxicological Sciences. Vol. 24, Pg. 337, 1999. |
rat |
LD50 |
intramuscular |
9200ug/kg (9.2mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BLOOD: NORMOCYTIC ANEMIA |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 723, 1982. |
rat |
LD50 |
intraperitoneal |
6400ug/kg (6.4mg/kg) |
? |
Journal of Toxicological Sciences. Vol. 18, Pg. 31, 1993. |
rat |
LD50 |
intravenous |
8mg/kg (8mg/kg) |
KIDNEY, URETER, AND BLADDER: OTHER CHANGES |
JNCI, Journal of the National Cancer Institute. Vol. 67, Pg. 201, 1981. |
rat |
LD50 |
oral |
25800ug/kg (25.8mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BLOOD: NORMOCYTIC ANEMIA |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 723, 1982. |
rat |
LD50 |
subcutaneous |
8100ug/kg (8.1mg/kg) |
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED |
Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 5669, 1981. |