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Cisplatin cas no:15663-27-1

Synonyms: Neoplatin;Platosin;cis-dichlorodi-ammine platinum(ii);cis-Diammineplatinum(II) dichloride;cis-Dichlorodiamminoplatinum(II);CPDD;cisPt(II);cis-Platinum(II) diaminodichloride;Platinum(II), diamminedichloro-, cis-;Biocisplatinum;Cisplatyl;DDP (antitumor agent);Cisplatinum;azane; platinum(+2) cation; dichloride;

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Identification
NameCisplatin
CAS15663-27-1
SynonymsNeoplatin;Platosin;cis-dichlorodi-ammine platinum(ii);cis-Diammineplatinum(II) dichloride;cis-Dichlorodiamminoplatinum(II);CPDD;cisPt(II);cis-Platinum(II) diaminodichloride;Platinum(II), diamminedichloro-, cis-;Biocisplatinum;Cisplatyl;DDP (antitumor agent);Cisplatinum;azane; platinum(+2) cation; dichloride;
EINECS(EC#)239-733-8
Molecular FormulaCl2H6N2Pt
Molecular Weight300.05
Chemical Properties
AppearanceOrange-yellow to deep yellow solid or powder
storage tempStore in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked. Keep containers tightly closed.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Safety Data

Hazard T:Toxic
Risk R45;R25;R41
Safety

Hazard Codes of Cisplatin (CAS NO.15663-27-1):?ToxicT
Risk Statements: 45-25-41-60-46-42/43-36/37/38
R45:May cause cancer.?
R25 :Toxic if swallowed.?
R41:Risk of serious damage to the eyes.?
R60:May impair fertility.?
R46:May cause heritable genetic damage.?
R42/43:May cause sensitization by inhalation and skin contact.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 53-26-39-45-99-36/37/39-22
S53:Avoid exposure - obtain special instructions before use.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S39:Wear eye / face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S22:Do not breathe dust.
RIDADR: UN 3288 6.1/PG 2
WGK Germany: 3
RTECS: TP2455000
F: 10-21
HazardClass: 6.1(a)
PackingGroup: II


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo unreported 19200ug/kg/12 (19.2mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR Journal of Pediatrics. Vol. 103, Pg. 1006, 1983.
dog LDLo intravenous 2500ug/kg (2.5mg/kg) GASTROINTESTINAL: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN		 Toxicology and Applied Pharmacology. Vol. 25, Pg. 230, 1973.
frog LD50 parenteral 17mg/kg (17mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"		 Journal of Comparative Pathology. Vol. 103, Pg. 387, 1990.
guinea pig LD50 intraperitoneal 9700ug/kg (9.7mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR Toxicology and Applied Pharmacology. Vol. 33, Pg. 320, 1975.
human TDLo intradermal 40ng/kg (0.00004mg/kg) SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE

SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE		 Cancer Research. Vol. 35, Pg. 2766, 1975.
human TDLo intravenous 500ug/kg/13D- (0.5mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED

BLOOD: OTHER CHANGES		 Cancer Treatment Reports. Vol. 62, Pg. 693, 1978.
human TDLo intravenous 1500ug/kg/6D- (1.5mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR

KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE		 Cancer Chemotherapy Reports, Part 1. Vol. 57, Pg. 191, 1973.
human TDLo intravenous 2500ug/kg (2.5mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

GASTROINTESTINAL: NAUSEA OR VOMITING

KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED		 Cancer Chemotherapy Reports, Part 1. Vol. 59, Pg. 647, 1975.
human TDLo intravenous 72mg/kg/25D-I (72mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Cancer Treatment Reports. Vol. 62, Pg. 1591, 1978.
mammal (species unspecified) LDLo intravenous 8mg/kg (8mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 28(4), Pg. 285, 2000.
man TDLo intravenous 2140ug/kg/5D- (2.14mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Japanese Journal of Medicine. Vol. 23, Pg. 283, 1984.
man TDLo parenteral 2140ug/kg/5D- (2.14mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Nippon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine. Vol. 72, Pg. 1426, 1983.
monkey LDLo intravenous 250ug/kg (0.25mg/kg) ? Cancer Vol. 33, Pg. 1219, 1974.
mouse LD50 intramuscular 17900ug/kg (17.9mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: NORMOCYTIC ANEMIA		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 723, 1982.
mouse LD50 intraperitoneal 6600ug/kg (6.6mg/kg) ? Journal of Medicinal Chemistry. Vol. 34, Pg. 414, 1991.
mouse LD50 intravenous 11mg/kg (11mg/kg) ? Archives of Toxicology, Supplement. Vol. 7, Pg. 90, 1984.
mouse LD50 oral 32700ug/kg (32.7mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED		 Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 5669, 1981.
mouse LD50 parenteral 22mg/kg (22mg/kg) ? International Journal of Radiation Oncology, Biology, Physics. Vol. 5, Pg. 1417, 1979.
mouse LD50 subcutaneous 13mg/kg (13mg/kg) ? Journal de Pharmacie de Belgique. Vol. 41, Pg. 286, 1986.
mouse LD50 unreported 10900ug/kg (10.9mg/kg) ? Gan to Kagaku Ryoho. Cancer and Chemotherapy. Vol. 13, Pg. 280, 1986.
rat LD unreported > 5mg/kg (5mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Journal of Toxicological Sciences. Vol. 24, Pg. 337, 1999.
rat LD50 intramuscular 9200ug/kg (9.2mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: NORMOCYTIC ANEMIA		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 723, 1982.
rat LD50 intraperitoneal 6400ug/kg (6.4mg/kg) ? Journal of Toxicological Sciences. Vol. 18, Pg. 31, 1993.
rat LD50 intravenous 8mg/kg (8mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES JNCI, Journal of the National Cancer Institute. Vol. 67, Pg. 201, 1981.
rat LD50 oral 25800ug/kg (25.8mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: NORMOCYTIC ANEMIA		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 723, 1982.
rat LD50 subcutaneous 8100ug/kg (8.1mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED		 Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 5669, 1981.

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