15663-27-1|CisplatinProducts Supply - Chemical intermediates Network

Cisplatin cas no:15663-27-1

Synonyms: Neoplatin;Platosin;cis-dichlorodi-ammine platinum(ii);cis-Diammineplatinum(II) dichloride;cis-Dichlorodiamminoplatinum(II);CPDD;cisPt(II);cis-Platinum(II) diaminodichloride;Platinum(II), diamminedichloro-, cis-;Biocisplatinum;Cisplatyl;DDP (antitumor agent);Cisplatinum;azane; platinum(+2) cation; dichloride;

Identification

NameCisplatin
CAS15663-27-1
SynonymsNeoplatin;Platosin;cis-dichlorodi-ammine platinum(ii);cis-Diammineplatinum(II) dichloride;cis-Dichlorodiamminoplatinum(II);CPDD;cisPt(II);cis-Platinum(II) diaminodichloride;Platinum(II), diamminedichloro-, cis-;Biocisplatinum;Cisplatyl;DDP (antitumor agent);Cisplatinum;azane; platinum(+2) cation; dichloride;
EINECS(EC#)239-733-8
Molecular FormulaCl₂H₆N₂Pt
Molecular Weight300.05

Chemical Properties

AppearanceOrange-yellow to deep yellow solid or powder
storage tempStore in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked. Keep containers tightly closed.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(a)

Safety Data

Hazard T:Toxic
Risk R45;R25;R41
Safety

Hazard Codes of Cisplatin (CAS NO.15663-27-1):? Toxic T
Risk Statements: 45-25-41-60-46-42/43-36/37/38
R45:May cause cancer.?
R25 :Toxic if swallowed.?
R41:Risk of serious damage to the eyes.?
R60:May impair fertility.?
R46:May cause heritable genetic damage.?
R42/43:May cause sensitization by inhalation and skin contact.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 53-26-39-45-99-36/37/39-22
S53:Avoid exposure - obtain special instructions before use.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S39:Wear eye / face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S22:Do not breathe dust.
RIDADR: UN 3288 6.1/PG 2
WGK Germany: 3
RTECS: TP2455000
F: 10-21
HazardClass: 6.1(a)
PackingGroup: II

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	unreported	19200ug/kg/12 (19.2mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR	Journal of Pediatrics. Vol. 103, Pg. 1006, 1983.
dog	LDLo	intravenous	2500ug/kg (2.5mg/kg)	GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Toxicology and Applied Pharmacology. Vol. 25, Pg. 230, 1973.
frog	LD50	parenteral	17mg/kg (17mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Journal of Comparative Pathology. Vol. 103, Pg. 387, 1990.
guinea pig	LD50	intraperitoneal	9700ug/kg (9.7mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR	Toxicology and Applied Pharmacology. Vol. 33, Pg. 320, 1975.
human	TDLo	intradermal	40ng/kg (0.00004mg/kg)	SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE	Cancer Research. Vol. 35, Pg. 2766, 1975.
human	TDLo	intravenous	500ug/kg/13D- (0.5mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED BLOOD: OTHER CHANGES	Cancer Treatment Reports. Vol. 62, Pg. 693, 1978.
human	TDLo	intravenous	1500ug/kg/6D- (1.5mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Cancer Chemotherapy Reports, Part 1. Vol. 57, Pg. 191, 1973.
human	TDLo	intravenous	2500ug/kg (2.5mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED	Cancer Chemotherapy Reports, Part 1. Vol. 59, Pg. 647, 1975.
human	TDLo	intravenous	72mg/kg/25D-I (72mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Cancer Treatment Reports. Vol. 62, Pg. 1591, 1978.
mammal (species unspecified)	LDLo	intravenous	8mg/kg (8mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 28(4), Pg. 285, 2000.
man	TDLo	intravenous	2140ug/kg/5D- (2.14mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Japanese Journal of Medicine. Vol. 23, Pg. 283, 1984.
man	TDLo	parenteral	2140ug/kg/5D- (2.14mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Nippon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine. Vol. 72, Pg. 1426, 1983.
monkey	LDLo	intravenous	250ug/kg (0.25mg/kg)	?	Cancer Vol. 33, Pg. 1219, 1974.
mouse	LD50	intramuscular	17900ug/kg (17.9mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: NORMOCYTIC ANEMIA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 723, 1982.
mouse	LD50	intraperitoneal	6600ug/kg (6.6mg/kg)	?	Journal of Medicinal Chemistry. Vol. 34, Pg. 414, 1991.
mouse	LD50	intravenous	11mg/kg (11mg/kg)	?	Archives of Toxicology, Supplement. Vol. 7, Pg. 90, 1984.
mouse	LD50	oral	32700ug/kg (32.7mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 5669, 1981.
mouse	LD50	parenteral	22mg/kg (22mg/kg)	?	International Journal of Radiation Oncology, Biology, Physics. Vol. 5, Pg. 1417, 1979.
mouse	LD50	subcutaneous	13mg/kg (13mg/kg)	?	Journal de Pharmacie de Belgique. Vol. 41, Pg. 286, 1986.
mouse	LD50	unreported	10900ug/kg (10.9mg/kg)	?	Gan to Kagaku Ryoho. Cancer and Chemotherapy. Vol. 13, Pg. 280, 1986.
rat	LD	unreported	> 5mg/kg (5mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Journal of Toxicological Sciences. Vol. 24, Pg. 337, 1999.
rat	LD50	intramuscular	9200ug/kg (9.2mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: NORMOCYTIC ANEMIA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 723, 1982.
rat	LD50	intraperitoneal	6400ug/kg (6.4mg/kg)	?	Journal of Toxicological Sciences. Vol. 18, Pg. 31, 1993.
rat	LD50	intravenous	8mg/kg (8mg/kg)	KIDNEY, URETER, AND BLADDER: OTHER CHANGES	JNCI, Journal of the National Cancer Institute. Vol. 67, Pg. 201, 1981.
rat	LD50	oral	25800ug/kg (25.8mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: NORMOCYTIC ANEMIA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 723, 1982.
rat	LD50	subcutaneous	8100ug/kg (8.1mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 5669, 1981.

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Cisplatin cas no:15663-27-1

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