child |
LDLo |
oral |
469mg/kg (469mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Annals of Emergency Medicine. Vol. 15, Pg. 1308, 1986. |
child |
TDLo |
oral |
480mg/kg/17D- (480mg/kg) |
LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" |
Journal of Pediatrics. Vol. 90, Pg. 657, 1977. |
child |
TDLo |
oral |
500mg/kg (500mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
Annals of Pharmacotherpy. Vol. 31, Pg. 432, 1997. |
guinea pig |
LD50 |
oral |
495mg/kg (495mg/kg) |
? |
Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984. |
hamster |
LD50 |
oral |
1690mg/kg (1690mg/kg) |
? |
Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984. |
mammal (species unspecified) |
LD50 |
oral |
1gm/kg (1000mg/kg) |
? |
Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 42, Pg. 545, 1985. |
man |
LDLo |
oral |
171mg/kg (171mg/kg) |
BEHAVIORAL: GENERAL ANESTHETIC
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION |
British Medical Journal. Vol. 281, Pg. 1458, 1980. |
man |
TDLo |
oral |
120mg/kg/W-I (120mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
New York State Journal of Medicine. Vol. 78, Pg. 1239, 1978. |
man |
TDLo |
oral |
180mg/kg/3W-I (180mg/kg) |
LIVER: "JAUNDICE, CHOLESTATIC" |
American Journal of Gastroenterology. Vol. 91, Pg. 1626, 1996. |
man |
TDLo |
oral |
429mg/kg (429mg/kg) |
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
Journal of Toxicology, Clinical Toxicology. Vol. 32, Pg. 315, 1994. |
man |
TDLo |
oral |
800mg/kg (800mg/kg) |
BEHAVIORAL: COMA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Postgraduate Medical Journal. Vol. 69, Pg. 575, 1993. |
man |
TDLo |
oral |
1028mg/kg (1028mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
American Journal of Emergency Medicine. Vol. 13, Pg. 375, 1995. |
mouse |
LD50 |
intraperitoneal |
320mg/kg (320mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH |
Toxicology and Applied Pharmacology. Vol. 15, Pg. 310, 1969.
Link to PubMed |
mouse |
LD50 |
oral |
740mg/kg (740mg/kg) |
BEHAVIORAL: ANALGESIA |
Pharmaceutical Chemistry Journal Vol. 14, Pg. 119, 1980. |
mouse |
LD50 |
rectal |
620mg/kg (620mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982. |
mouse |
LD50 |
subcutaneous |
395mg/kg (395mg/kg) |
? |
Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982. |
rabbit |
LD50 |
oral |
1400mg/kg (1400mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 1032, 1990. |
rabbit |
LD50 |
rectal |
830mg/kg (830mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 1032, 1990. |
rat |
LD50 |
intraperitoneal |
626mg/kg (626mg/kg) |
BEHAVIORAL: ANALGESIA |
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1006, 1977. |
rat |
LD50 |
oral |
636mg/kg (636mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 280, 1984. |
rat |
LD50 |
rectal |
530mg/kg (530mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982. |
rat |
LD50 |
subcutaneous |
740mg/kg (740mg/kg) |
? |
Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982. |
women |
TDLo |
oral |
8mg/kg (8mg/kg) |
BEHAVIORAL: HEADACHE |
JAMA, Journal of the American Medical Association. Vol. 239, Pg. 1062, 1978. |
women |
TDLo |
oral |
132mg/kg/6D-I (132mg/kg) |
BLOOD: THROMBOCYTOPENIA |
British Journal of Clinical Practice. Vol. 48, Pg. 51, 1994. |
women |
TDLo |
unreported |
96mg/kg/3D-I (96mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE |
JAMA, Journal of the American Medical Association. Vol. 248, Pg |