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Ibuprofen cas no:15687-27-1

Synonyms: alpha-methyl-4-(2-methylpropyl)benzeneacetic acid; 2-(4-isobutylphenyl)-propionic acid; p-isobutylhydratropic acid; RARECHEM AL BO 0989; MOTRIN(TM); (+/-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID; 2-(4-ISOBUTYLPHENYL)PROPIONIC ACID; 4-ISOBUTYL-ALPHA-METHYLPHENYLACETIC ACID; AKOS NCG1-0060; (+/-)-ALPHA-METHYL-4-(2-METHYLPROPYL)-BENZENEACETIC ACID; ALPHA-METHYL-4-[2-METHYLPROPYL]BENZENEACETIC ACID

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Identification
NameIbuprofen
CAS15687-27-1
Synonymsalpha-methyl-4-(2-methylpropyl)benzeneacetic acid; 2-(4-isobutylphenyl)-propionic acid; p-isobutylhydratropic acid; RARECHEM AL BO 0989; MOTRIN(TM); (+/-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID; 2-(4-ISOBUTYLPHENYL)PROPIONIC ACID; 4-ISOBUTYL-ALPHA-METHYLPHENYLACETIC ACID; AKOS NCG1-0060; (+/-)-ALPHA-METHYL-4-(2-METHYLPROPYL)-BENZENEACETIC ACID; ALPHA-METHYL-4-[2-METHYLPROPYL]BENZENEACETIC ACID
EINECS(EC#)239-784-6
Molecular FormulaC13H18O2
Molecular Weight206.28
Chemical Properties
AppearanceColourless, Crystalline Solid
storage tempStore in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard Xn:Harmful
Risk R22;R51/53;R63
Safety

Hazard Codes:?HarmfulXn,DangerousN
Risk Statements: 22-63-51/53
R22:?Harmful if swallowed?
R63: Possible risk of harm to the unborn child?
R51/53:?Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Statements: 61-36/37
S61:?Avoid release to the environment. Refer to special instructions safety data sheet?
S36/37:? Wear suitable protective clothing and gloves
RIDADR: 2811
WGK Germany: 3
RTECS: MU6640000
HazardClass: 6.1(b)
PackingGroup: III


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child LDLo oral 469mg/kg (469mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Annals of Emergency Medicine. Vol. 15, Pg. 1308, 1986.
child TDLo oral 480mg/kg/17D- (480mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" Journal of Pediatrics. Vol. 90, Pg. 657, 1977.
child TDLo oral 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"		 Annals of Pharmacotherpy. Vol. 31, Pg. 432, 1997.
guinea pig LD50 oral 495mg/kg (495mg/kg) ? Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
hamster LD50 oral 1690mg/kg (1690mg/kg) ? Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
mammal (species unspecified) LD50 oral 1gm/kg (1000mg/kg) ? Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 42, Pg. 545, 1985.
man LDLo oral 171mg/kg (171mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 British Medical Journal. Vol. 281, Pg. 1458, 1980.
man TDLo oral 120mg/kg/W-I (120mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 New York State Journal of Medicine. Vol. 78, Pg. 1239, 1978.
man TDLo oral 180mg/kg/3W-I (180mg/kg) LIVER: "JAUNDICE, CHOLESTATIC" American Journal of Gastroenterology. Vol. 91, Pg. 1626, 1996.
man TDLo oral 429mg/kg (429mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"		 Journal of Toxicology, Clinical Toxicology. Vol. 32, Pg. 315, 1994.
man TDLo oral 800mg/kg (800mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Postgraduate Medical Journal. Vol. 69, Pg. 575, 1993.
man TDLo oral 1028mg/kg (1028mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" American Journal of Emergency Medicine. Vol. 13, Pg. 375, 1995.
mouse LD50 intraperitoneal 320mg/kg (320mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH		 Toxicology and Applied Pharmacology. Vol. 15, Pg. 310, 1969.
Link to PubMed
mouse LD50 oral 740mg/kg (740mg/kg) BEHAVIORAL: ANALGESIA Pharmaceutical Chemistry Journal Vol. 14, Pg. 119, 1980.
mouse LD50 rectal 620mg/kg (620mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982.
mouse LD50 subcutaneous 395mg/kg (395mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982.
rabbit LD50 oral 1400mg/kg (1400mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 1032, 1990.
rabbit LD50 rectal 830mg/kg (830mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 1032, 1990.
rat LD50 intraperitoneal 626mg/kg (626mg/kg) BEHAVIORAL: ANALGESIA Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1006, 1977.
rat LD50 oral 636mg/kg (636mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 280, 1984.
rat LD50 rectal 530mg/kg (530mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982.
rat LD50 subcutaneous 740mg/kg (740mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982.
women TDLo oral 8mg/kg (8mg/kg) BEHAVIORAL: HEADACHE JAMA, Journal of the American Medical Association. Vol. 239, Pg. 1062, 1978.
women TDLo oral 132mg/kg/6D-I (132mg/kg) BLOOD: THROMBOCYTOPENIA British Journal of Clinical Practice. Vol. 48, Pg. 51, 1994.
women TDLo unreported 96mg/kg/3D-I (96mg/kg) SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE JAMA, Journal of the American Medical Association. Vol. 248, Pg

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