L-Norleucine,6-diazo-5-oxo- cas no:157-03-9

NameL-Norleucine,6-diazo-5-oxo-
CAS157-03-9
SynonymsNorleucine,6-diazo-5-oxo-, L- (8CI);6-Diazo-5-oxo-L-norleucine;DON;DON(pharmaceutical);L-6-Diazo-5-oxonorleucine;L-DON;NSC 7365;
Molecular FormulaC6H9 N3 O3
Molecular Weight171.18

storage temp−20°C

Hazard T
Safety

Poison by ingestion, intraperitoneal, and intravenous routes. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes: T
Risk Statements: 23/24/25
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed
Safety Statements: 36/37/39-45
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: RC6340000
F: 8

1.		pic-esc 5 µg/plate		CNREA8    Cancer Research. 43 (1983),2819.
2.		ipr-rat LD50:80 mg/kg		CPCHAO    Clinical Proceedings of the Childrens Hospital of the District of Columbia. 18 (1962),307.
3.		orl-mus LD50:197 mg/kg		NCISP*    National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 .
4.		ipr-mus LDLo:300 mg/kg		JOENAK    Journal of Endocrinology. 18 (1959),204.
5.		ivn-mus LD50:74 mg/kg		85ERAY    Antibiotics: Origin, Nature, and Properties. 2 (1978),1253.