Pazufloxacin mesilate cas no:163680-77-1
Synonyms: (-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-;
NamePazufloxacin mesilate
CAS163680-77-1
Synonyms(-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-;
Molecular FormulaC16H15FN2O4.CH4O3S
Molecular Weight414.4
Appearancecrystalline solid
Hazard Xi: Irritant;C: Corrosive;F: Flammable;
Risk R36/37/38
Safety
Hazard Codes:?
Xi,?
C,?
F
Risk Statements: 36/37/38-34-11?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R11:Highly flammable.
Safety Statements: 26-45-36/37/39-16?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S16:Keep away from sources of ignition.
RTECS: UU8815400
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LDLo |
intravenous |
521mg/kg (521mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS |
Japanese Journal of Antibiotics. Vol. 51, Pg. 583, 1998.
? |
| monkey |
LDLo |
intravenous |
520mg/kg (520mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Japanese Journal of Antibiotics. Vol. 51, Pg. 583, 1998.
? |
| rat |
LDLo |
intravenous |
391mg/kg (391mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Japanese Journal of Antibiotics. Vol. 51, Pg. 583, 1998.
? |
