Tetradecanoic acid,(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester cas no:16561-29-8
Synonyms: Myristicacid, 9-ester with 1,1aa,1bb,4,4a,7aa,7b,8,9,9a-decahydro-4ab,7ba,9b,9aa-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8a-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one9a-acetate, (+)- (8CI); Tetradecanoic acid,9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester, [1aR-(1aa,1bb,4ab,7aa,7ba,8a,9b,9aa)]-;1H-Cyclopropa[3,4]benz[1,2-e]azulene, tetradecanoic acid deriv.;12-O-Tetradecanoylphorbol 13-acetate; 12-Tetradecanoylphorbol 13-acetate;12-Tetradecanoylphorbol 13-monoacetate; 13-O-Acetylphorbol 12-myristate; 4b-Phorbol 12-myristate 13-acetate;Factor A1; Factor A1 (croton oil); NSC 262244; PMA; PMA (tumor promoter);Phorbol 12-myristate 13-acetate; Phorbol 12-tetradecanoate 13-acetate; Phorbolmyristate acetate; TPA; TPA (phorbol derivative); b-Phorbol 12-myristate 13-acetate
NameTetradecanoic acid,(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester
CAS16561-29-8
SynonymsMyristicacid, 9-ester with 1,1aa,1bb,4,4a,7aa,7b,8,9,9a-decahydro-4ab,7ba,9b,9aa-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8a-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one9a-acetate, (+)- (8CI); Tetradecanoic acid,9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester, [1aR-(1aa,1bb,4ab,7aa,7ba,8a,9b,9aa)]-;1H-Cyclopropa[3,4]benz[1,2-e]azulene, tetradecanoic acid deriv.;12-O-Tetradecanoylphorbol 13-acetate; 12-Tetradecanoylphorbol 13-acetate;12-Tetradecanoylphorbol 13-monoacetate; 13-O-Acetylphorbol 12-myristate; 4b-Phorbol 12-myristate 13-acetate;Factor A1; Factor A1 (croton oil); NSC 262244; PMA; PMA (tumor promoter);Phorbol 12-myristate 13-acetate; Phorbol 12-tetradecanoate 13-acetate; Phorbolmyristate acetate; TPA; TPA (phorbol derivative); b-Phorbol 12-myristate 13-acetate
EINECS(EC#)16561-29-8
Molecular FormulaC36H56 O8
Molecular Weight616.82504
AppearanceWhite to off-white solid.
refractive index1.553
storage temp−20°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Hazard Xi: Irritant;
Risk R38
Safety
Deadly poison by intravenous route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. A skin irritant. Questionable carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: 
Xi
Risk Statements: 38
R38:Irritating to skin.
Safety Statements: 36/37
S36/37:Wear suitable protective clothing and gloves.
RIDADR: 2928
WGK Germany: 3
RTECS: QH4377000
HazardClass: 6.1(a)
PackingGroup of Phorbol myristate acetate (CAS NO.16561-29-8): II
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| domestic animals - goat/sheep |
LDLo |
intravenous |
40ug/kg (0.04mg/kg) |
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT
BLOOD: CHANGES IN PLATELET COUNT |
Journal of Applied Physiology. Vol. 54, Pg. 267, 1983. |
| mouse |
LD |
intraperitoneal |
> 1mg/kg (1mg/kg) |
|
Toxicon. Vol. 38, Pg. 123, 2000. |
| mouse |
LD50 |
intravenous |
309ug/kg (0.309mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Agents and Actions, A Swiss Journal of Pharmacology. Vol. 16, Pg. 535, 1985. |
