Card-20(22)-enolide,3,12,14-trihydroxy-, (3b,5b,12b)- cas no:1672-46-4

NameCard-20(22)-enolide,3,12,14-trihydroxy-, (3b,5b,12b)-
CAS1672-46-4
Synonyms5b-Card-20(22)-enolide, 3b,12b,14-trihydroxy- (8CI); Digoxigenin (6CI); 12b-Hydroxydigitoxigenin; 3b,12b,14-Trihydroxycard-20(22)-enolide; 3b-Digoxigenin; Lanadigenin; D20:22-3b,12b,14,21-Tetrahydroxynorcholenic acid lactone
EINECS(EC#)216-806-2
Molecular FormulaC23H34 O5
Molecular Weight390.57

Appearancewhite solid
refractive index1.609

Hazardclass6.1(a)

Hazard T+: Very toxic;
Risk R26/27/28
Safety

Safety Information of Digoxigenine (CAS NO.1672-46-4):
Hazard Codes: T+
Risk Statements: 26/27/28
26:  Very Toxic by inhalation 
27:  Very Toxic in contact with skin 
28:  Very Toxic if swallowed   
Safety Statements: 36/37/39-45
36:  Wear suitable protective clothing  
37:  Wear suitable gloves  
39:  Wear eye/face protection
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	244ug/kg (0.244mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Journal of the American Pharmaceutical Association. Vol. 27, Pg. 189, 1938.
cat	LDLo	unreported	285ug/kg (0.285mg/kg)		"Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963Vol. -, Pg. 55, 1963.
guinea pig	LDLo	intravenous	3545ug/kg (3.545mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 153, Pg. 436, 1965.
pigeon	LDLo	parenteral	1620ug/kg (1.62mg/kg)		Chemical and Pharmaceutical Bulletin. Vol. 8, Pg. 18, 1960.