4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-,(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)- cas no:1695-77-8
Synonyms: 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)- (7CI,8CI);4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, [2R-(2a,4ab,5ab,6b,7b,8b,9a,9aa,10ab)]-;Actinospectacin;Antibiotic 2233wp;Espectinomicina;M 141;Spectacin;Spectam;Togamycin;Trobicin;U 18409E;
Name4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-,(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-
CAS1695-77-8
Synonyms4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)- (7CI,8CI);4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, [2R-(2a,4ab,5ab,6b,7b,8b,9a,9aa,10ab)]-;Actinospectacin;Antibiotic 2233wp;Espectinomicina;M 141;Spectacin;Spectam;Togamycin;Trobicin;U 18409E;
EINECS(EC#)216-911-3
Molecular FormulaC14H24N2O7
Molecular Weight332.35
Appearancea white to pale buff crystalline dihydrochloride pentahydrate powder
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| cat |
LD |
intravenous |
> 800mg/kg (800mg/kg) |
BEHAVIORAL: ATAXIA |
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 507, 1961. |
| dog |
LD |
oral |
> 1gm/kg (1000mg/kg) |
|
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 507, 1961. |
| monkey |
LD |
oral |
> 500mg/kg (500mg/kg) |
|
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 507, 1961. |
| mouse |
LD |
intravenous |
> 2gm/kg (2000mg/kg) |
BEHAVIORAL: MUSCLE WEAKNESS
GASTROINTESTINAL: NAUSEA OR VOMITING
BEHAVIORAL: ATAXIA |
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 507, 1961. |
| mouse |
LD50 |
intravenous |
2gm/kg (2000mg/kg) |
|
"Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 105, 1967. |
| mouse |
LDLo |
oral |
20gm/kg (20000mg/kg) |
|
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 507, 1961. |
| rabbit |
LD |
unreported |
> 40mg/kg (40mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 507, 1961. |
| rat |
LD50 |
intraperitoneal |
5724mg/kg (5724mg/kg) |
|
Bollettino Chimico Farmaceutico. Vol. 111, Pg. 265, 1972. |
| rat |
LD50 |
oral |
> 5gm/kg (5000mg/kg) |
|
Bollettino Chimico Farmaceutico. Vol. 111, Pg. 265, 1972. |
