Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol,(17α)- cas no:17230-88-5
Synonyms: 17a-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol(8CI);1H-Cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol, 1-ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-(7CI);Bonzol;Cyclomen;Danalem;Danazolum;Danocrine;Danol;Ladogal;NSC 270916;Win 17757;Winobanin;
NamePregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol,(17α)-
CAS17230-88-5
Synonyms17a-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol(8CI);1H-Cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol, 1-ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-(7CI);Bonzol;Cyclomen;Danalem;Danazolum;Danocrine;Danol;Ladogal;NSC 270916;Win 17757;Winobanin;
EINECS(EC#)241-270-1
Molecular FormulaC22H27NO2
Molecular Weight337.46
AppearanceWhite solid
refractive index1.604
Hazard Xn:Harmful
Risk R20/21/22;R63
Safety
Human systemic effects by ingestion: allergic dermatitis. Human male reproductive effects by ingestion: changes in spermatogenesis, impotence, and other unspecified effects. Human female reproductive effects by ingestion: menstrual cycle changes or disorders, changes in fertility, and other unspecified effects. Other experimental reproductive effects. Questionable human carcinogen producing liver tumors. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:?
Xn,
Xi
Risk Statements: 20/21/22-63-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R63:Possible risk of harm to the unborn child.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-36-37/39-26?
S22:Do not breathe dust.?
S36:Wear suitable protective clothing.?
S37/39:Wear suitable gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS of Danazol (CAS NO.17230-88-5): TU4157070
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD50 |
oral |
> 5gm/kg (5000mg/kg) |
? |
Journal of International Medical Research. Vol. 5(Suppl, |
| man |
TDLo |
oral |
274mg/kg/32D- (274mg/kg) |
LIVER: "JAUNDICE, CHOLESTATIC"
LIVER: OTHER CHANGES
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Postgraduate Medical Journal. Vol. 69, Pg. 237, 1993. |
| man |
TDLo |
oral |
1029mg/kg/17W (1029mg/kg) |
LIVER: "JAUNDICE, CHOLESTATIC" |
Postgraduate Medical Journal. Vol. 68, Pg. 984, 1992. |
| mouse |
LD50 |
intraperitoneal |
6770mg/kg (6770mg/kg) |
? |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983. |
| mouse |
LD50 |
oral |
4830mg/kg (4830mg/kg) |
? |
Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 25, Pg. 55, 1990. |
| mouse |
LD50 |
subcutaneous |
> 10gm/kg (10000mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 25, Pg. 691, 1983. |
| rabbit |
LD50 |
oral |
> 5gm/kg (5000mg/kg) |
? |
Journal of International Medical Research. Vol. 5(Suppl, |
| rat |
LD50 |
intraperitoneal |
> 10gm/kg (10000mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 25, Pg. 691, 1983. |
| rat |
LD50 |
oral |
> 17gm/kg (17000mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 25, Pg. 691, 1983. |
| rat |
LD50 |
subcutaneous |
> 10gm/kg (10000mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 25, Pg. 691, 1983. |
| women |
TDLo |
oral |
120mg/kg/10D- (120mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" |
Archives of Internal Medicine. Vol. 145, Pg. 2251, 1985. |
| women |
TDLo |
oral |
974mg/kg/23W- (974mg/kg) |
PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE
BEHAVIORAL: HEADACHE |
Therapie. Vol. 43, Pg. 501, 1988. |
