3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione,hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-,(1aR,2aR,3S,6R,6aS,8aS,8bR,9R)- cas no:17617-45-7

Name3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione,hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-,(1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-
CAS17617-45-7
Synonyms3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione,hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-, [1aR-(1aa,2ab,3b,6b,6ab,8aS*,8bb,9R*)]-; Picrotoxinin (6CI,7CI); (-)-Picrotoxinin; NSC 129537
Molecular FormulaC15H16 O6
Molecular Weight292.31

refractive index1.625

Hazardclass6.1(a)

Hazard T+: Very toxic;
Risk 25-28
Safety

Poison by subcutaneous, intracerebral, and intramuscular routes. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information of Picrotoxinin (CAS NO.17617-45-7):
Hazard Codes: T+
Risk Statements: 25-28 
25:  Toxic if swallowed 
28:  Very Toxic if swallowed 
Safety Statements: 13-20-45-36/37-28
13:  Keep away from food, drink and animal feeding stuffs
20:  When using, do not eat or drink 
28:  After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 
36:  Wear suitable protective clothing  
37:  Wear suitable gloves 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	subcutaneous	1100ug/kg (1.1mg/kg)		"Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
frog	LDLo	subcutaneous	1100ug/kg (1.1mg/kg)		"Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
mouse	LD50	intracrebral	10ug/kg (0.01mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology Letters. Vol. 60, Pg. 289, 1992.
mouse	LD50	intraperitoneal	8980ug/kg (8.98mg/kg)		Current Toxicology. Vol. 1, Pg. 199, 1993.
mouse	LDLo	subcutaneous	1600ug/kg (1.6mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of the American Pharmaceutical Association. Vol. 23, Pg. 98, 1934.
pigeon	LDLo	intramuscular	1600ug/kg (1.6mg/kg)		Journal of the American Pharmaceutical Association. Vol. 23, Pg. 98, 1934.
pigeon	LDLo	subcutaneous	1600ug/kg (1.6mg/kg)		"Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit	LDLo	subcutaneous	1350ug/kg (1.35mg/kg)		"Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.